Protocadherin-7 Regulates Monocyte Migration Through Regulation of Small GTPase RhoA and Rac1.

Hyunsoo Kim, Noriko Takegahara, Yongwon Choi

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hyunsoo KimDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0009-0003-4777-5735

Noriko TakegaharaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Yongwon ChoiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Funding

Protocadherin 7 and Osteoclast MaturationR01AR077526 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI CHOI, YONGWON · 2020 to 2025

$1.8M

NIAMS NIH HHS AR077526NIAMS NIH HHS R01 AR077526

6 · The paper itself

Abstract

Protocadherin-7 (Pcdh7) is a member of the non-clustered protocadherin δ1 subgroup within the cadherin superfamily. Pcdh7 has been shown to control osteoclast differentiation via the protein phosphatase 2A (PP2A)-glycogen synthase kinase-3β (GSK3β)-small GTPase signaling axis. As protocadherins serve multiple biological functions, a deeper understanding of Pcdh7's biological features is valuable. Using an in vitro mouse monocyte cell culture system, we demonstrate that Pcdh7 plays a role in regulating monocyte migration by modulating the small GTPases RhoA and Rac1. Pcdh7-deficient (

Indexed as

CadherinsCell MovementMonocytesNeuropeptidesrac1 GTP-Binding ProteinrhoA GTP-Binding ProteinAnimalsCells, CulturedGlycogen Synthase Kinase 3 betaMiceMice, KnockoutProtocadherinsSignal TransductionCadherinsGlycogen Synthase Kinase 3 betaNeuropeptidesProtocadherinsrac1 GTP-Binding ProteinRac1 protein, mouserhoA GTP-Binding ProteinRhoA protein, mouseGSK3βmonocyte migrationPcdh7PP2ARac1RhoA

Identifiers

PMID39859288

DOI10.3390/ijms26020572

PMCPMC11766416

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.