ArticleInternational journal of molecular sciences2025
Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats.
Thayná Queiroz Menezes da Silva, Erikles Macêdo Barbosa, Luciano Cardoso Santos, Luciana Santos de Oliveira, Maria Clara da Silva Galrão Cunha, Isabella Oliveira de Macedo, Brenda Geovana Campos Martins, Cibele Luz Oliveira, Natalia Panhoca Rodrigues, Roberta Araújo-Lopes and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Thayná Queiroz Menezes da SilvaElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
Erikles Macêdo BarbosaElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.ORCID 0000-0002-3639-9223 Luciano Cardoso SantosElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.ORCID 0000-0001-7679-1353 Luciana Santos de OliveiraElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
Maria Clara da Silva Galrão CunhaElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
Isabella Oliveira de MacedoElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
Brenda Geovana Campos MartinsElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
Cibele Luz OliveiraElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
Natalia Panhoca RodriguesElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
Roberta Araújo-LopesEndocrinology and Metabolism Laboratory, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Raphael Escorsim SzawkaEndocrinology and Metabolism Laboratory, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-2639-3469 Juneo Freitas SilvaElectron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.ORCID 0000-0002-9881-1236 Funding
Universidade Estadual de Santa Cruz 073.11014.2023.0034257-82
6 · The paper itselfAbstract
Hypothyroidism causes ovarian dysfunction and infertility in women and animals and impairs the hypothalamic expression of kisspeptin (Kp). However, kisspeptin is also expressed in the genital system, and the lack of the Kp receptor (Kiss1r) in the uterus is linked to reduced implantation rates. This study investigated the impact of hypothyroidism on the uterine expression of Kp and Kiss1r in female rats throughout the estrous cycle and the associated changes in uterine activity modulators. Hypothyroidism was induced through daily administration of propylthiouracil (PTU) over a period of 14 days. Plasma levels of LH, E
Indexed as
Estrous CycleHypothyroidismKisspeptinsReceptors, Kisspeptin-1UterusAnimalsEstradiolEstrogen Receptor alphaFemaleLuteinizing HormoneProgesteronePropylthiouracilRatsRats, WistarReceptors, ProgesteroneEstradiolEstrogen Receptor alphaKiss1 protein, ratKiss1r protein, ratKisspeptinsLuteinizing HormoneProgesteronePropylthiouracilReceptors, Kisspeptin-1Receptors, Progesteroneestrous cyclehormone receptorskisspeptinthyroiduterus
Identifiers
PMID39859259
PMCPMC11765193
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