Evidence map›Paper›PMID 39859237›Full record

ArticleInternational journal of molecular sciences2025

OAS1: A Protective Mechanism for Alzheimer's Disease? An Exploration of Data and Possible Mechanisms.

Richard J Elsworthy, Alex Pearce, Farnoush Masoudzadeh, Klaudia Koska, Honey Lodhiya, Gargi Meher, Jodelle Adjej, Keeley J Brookes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Richard J ElsworthySchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-8504-9801
Alex PearceDepartment of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NF, UK.ORCID 0009-0009-8476-8685
Farnoush MasoudzadehDepartment of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NF, UK.
Klaudia KoskaDepartment of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NF, UK.
Honey LodhiyaDepartment of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NF, UK.
Gargi MeherDepartment of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NF, UK.
Jodelle AdjejDepartment of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NF, UK.
Keeley J BrookesDepartment of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NF, UK.ORCID 0000-0003-2427-2513

Funding

Alzheimer's Society Adding Value to the Brains for Dementia Research cohort with additional genetic data
6 · The paper itself

Abstract

The immune system and neuroinflammation are now well established in the aetiology of neurodegeneration. Previous studies of transcriptomic and gene association studies have highlighted the potential of the 2'-5' oligoadenylate synthetase 1 (OAS1) to play a role in Alzheimer's disease. OAS1 is a viral response gene, interferon-induced, dsRNA activated enzyme, which binds RNase L to degrade dsRNA, and has been associated with COVID-19 response. This study explores whether a viral defence gene could play a vital role in neurodegeneration pathology. The genotyping of five SNPs across the

Indexed as

2',5'-Oligoadenylate SynthetaseAlzheimer DiseaseAgedAged, 80 and overBrainFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMalePolymorphism, Single NucleotideRNA, Double-Stranded2',5'-Oligoadenylate SynthetaseOAS1 protein, humanRNA, Double-StrandedAlzheimer’s diseaseastrocytesdsRNAmoderatorOAS1

Identifiers

PMID39859237
PMCPMC11765370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.