Mendelian Randomization Study on hs-CRP and Dyslipidemia in Koreans: Identification of Novel SNP rs76400217.

Ximei Huang, Youngmin Han, Minjoo Kim

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Ximei HuangDepartment of Food and Nutrition, College of Life Science and Nano Technology, Hannam University, Daejeon 34054, Republic of Korea.

Youngmin HanInstitute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Republic of Korea.

Minjoo KimDepartment of Food and Nutrition, College of Life Science and Nano Technology, Hannam University, Daejeon 34054, Republic of Korea.ORCID 0000-0002-4261-9333

Funding

National Research Foundation of Korea NRF-2019R1I1A2A01061731National Research Foundation of Korea RS-2024-00355298

6 · The paper itself

Abstract

High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation and is associated with developing dyslipidemia. However, the causality between hs-CRP and dyslipidemia remains unresolved. This study aimed to investigate the relationship between hs-CRP concentrations and dyslipidemia and to explore the potential causal link using Mendelian randomization (MR) analysis. A nested case-control study was conducted with 1174 participants, and genotype data were analyzed using the Korean Chip. A genome-wide association study (GWAS) identified rs76400217 as a suitable instrumental variable (IV) due to its significant association with hs-CRP (

Indexed as

C-Reactive ProteinDyslipidemiasMendelian Randomization AnalysisPolymorphism, Single NucleotideAdultAgedCase-Control StudiesEast Asian PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedRepublic of KoreaC-Reactive Proteincausal relationshipdyslipidemiahigh-sensitivity C-reactive proteinMendelian randomization

Identifiers

PMID39859220

DOI10.3390/ijms26020506

PMCPMC11764716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.