Evidence map›Paper›PMID 39859210›Full record

ArticleInternational journal of molecular sciences2025

Sonic Hedgehog Determines Early Retinal Development and Adjusts Eyeball Architecture.

Noriyuki Azuma, Keiko Tadokoro, Masao Yamada, Masato Nakafuku, Hiroshi Nishina

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Candidate Genes for Non-Syndromic Pediatric Cataracts.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Noriyuki AzumaDepartment of Ophthalmology and Laboratory for Visual Science, National Centre for Child Health and Development, Tokyo 157-8535, Japan.ORCID 0000-0003-0332-8100
Keiko TadokoroDepartment of Genetics, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Masao YamadaDepartment of Genetics, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Masato NakafukuDepartment of Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
Hiroshi NishinaDepartment of Developmental and Regenerative Biology, Medical Research Institute, Institute of Science Tokyo, Tokyo 113-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The eye primordium of vertebrates initially forms exactly at the side of the head. Later, the eyeball architecture is tuned to see ahead with better visual acuity, but its molecular basis is unknown. The position of both eyes in the face alters in patients with holoprosencephaly due to

Indexed as

Hedgehog ProteinsRetinaAnimalsChick EmbryoFemaleGene Expression Regulation, DevelopmentalHoloprosencephalyHumansMaleMutation, MissensePAX6 Transcription FactorSignal TransductionHedgehog ProteinsPAX6 Transcription FactorSHH protein, humaneye architecturefoveaholoprosencephalyPax6retinal developmentSonic hedgehog

Identifiers

PMID39859210
PMCPMC11764597

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.