Evidence map›Paper›PMID 39859200›Full record

ArticleInternational journal of molecular sciences2025

Effects of Aneurysmal Subarachnoid Hemorrhage in Patients Without In-Hospital Infection on FABP-I, LBP, and sCD-14.

Brigitta Orban, Diana Simon, Szabina Erdo-Bonyar, Timea Berki, Tihamer Molnar, Laszlo Zavori, Attila Schwarcz, Zoltan Peterfi, Peter Csecsei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brigitta OrbanDepartment of Neurosurgery, Medical School, University of Pecs, 7622 Pecs, Hungary.
Diana SimonDepartment of Immunology and Biotechnology, Medical School, University of Pecs, 7622 Pecs, Hungary.
Szabina Erdo-BonyarDepartment of Immunology and Biotechnology, Medical School, University of Pecs, 7622 Pecs, Hungary.ORCID 0000-0002-9597-8487
Timea BerkiDepartment of Immunology and Biotechnology, Medical School, University of Pecs, 7622 Pecs, Hungary.
Tihamer MolnarDepartment of Anaesthesiology and Intensive Care, Medical School, University of Pecs, 7622 Pecs, Hungary.ORCID 0000-0002-6149-9787
Laszlo ZavoriEmergency Department, Saudi German Hospital, Dubai 61313, United Arab Emirates.ORCID 0000-0002-1715-4167
Attila SchwarczDepartment of Neurosurgery, Medical School, University of Pecs, 7622 Pecs, Hungary.
Zoltan Peterfi1st Department of Medicine, Medical School, University of Pecs, 7622 Pecs, Hungary.ORCID 0000-0001-9658-153X
Peter CsecseiDepartment of Neurosurgery, Medical School, University of Pecs, 7622 Pecs, Hungary.ORCID 0000-0002-4982-2481

Funding

National Laboratory for Translational Neuroscience project RRF-2.3.1-21-2022-00011National Research, Development and Innovation Office NKFI-FK-146159
6 · The paper itself

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition complicated by delayed cerebral ischemia (DCI), where inflammation plays a key role. Although altered gut permeability is noted in other conditions, its significance in aSAH remains unclear. Fatty acid-binding protein (FABP-I), lipopolysaccharide-binding protein (LBP), and soluble CD-14 (sCD-14) are established markers of barrier dysfunction. This study investigates gut permeability marker changes in early and late aSAH phases. The study included 177 aSAH patients and 100 controls. Serum samples were collected on days 1 (D1) and 9 (D9) after ictus. FABP-I, LBP, and sCD-14 levels were measured via ELISA, and clinical data were recorded. Outcomes were assessed using the 90-day modified Rankin scale (mRS 0-3 = favorable outcome). Serum FABP-I was significantly lower in aSAH patients (

Indexed as

Acute-Phase ProteinsCarrier ProteinsFatty Acid-Binding ProteinsLipopolysaccharide ReceptorsMembrane GlycoproteinsSubarachnoid HemorrhageAdultAgedBiomarkersCase-Control StudiesFemaleHumansLipopolysaccharide-Binding ProteinMaleMiddle AgedAcute-Phase ProteinsBiomarkersCarrier ProteinsCD14 protein, humanFABP1 protein, humanFatty Acid-Binding ProteinsLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsMembrane Glycoproteinsaneurysmal subarachnoid hemorrhageendotoxininflammationintestinal fatty acid binding protein (FABP-I)intestinal permeabilityleaky gut syndromelipopolysaccharide binding protein (LBP)sCD-14

Identifiers

PMID39859200
PMCPMC11764490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.