Evidence map›Paper›PMID 39859198›Full record

ArticleInternational journal of molecular sciences2025

Au

Olga V Repina, Alexey S Kubasov, Anna V Vologzhanina, Alexander V Borisov, Ilya S Kritchenkov, Ksenia M Voroshilkina, Alexey A Nazarov, Dmitriy M Shchevnikov, Mariya V Grudova, Rosa M Gomila and 4 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Crystal structure and Hirshfeld surface analysis of chlorido-(2,6-di-methyl-phenyl isocyanide)[Acta crystallographica. Section E, Crystallographic communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Olga V RepinaResearch Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Alexey S KubasovKurnakov Institute of General and Inorganic Chemistry, 31 Leninsky Prosp., 119991 Moscow, Russia.ORCID 0000-0002-0156-5535
Anna V VologzhaninaNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, 119334 Moscow, Russia.ORCID 0000-0002-6228-303X
Alexander V BorisovInstitute of Chemistry, R.E. Alekseev Nizhny Novgorod State Technical University, Minin St. 24, 603155 Nizhny Novgorod, Russia.ORCID 0000-0003-1765-5241
Ilya S KritchenkovResearch Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0003-0108-0690
Ksenia M VoroshilkinaDepartment of Chemistry, M.V. Lomonosov Moscow State University, 1 Leninskie Gory, 119991 Moscow, Russia.
Alexey A NazarovDepartment of Chemistry, M.V. Lomonosov Moscow State University, 1 Leninskie Gory, 119991 Moscow, Russia.ORCID 0000-0002-5821-1658
Dmitriy M ShchevnikovResearch Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0009-0000-9485-6341
Mariya V GrudovaResearch Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-1750-4323
Rosa M GomilaDepartament de Química, Universitat de les Illes Balears, 07122 Palma de Mallorca, Spain.ORCID 0000-0002-0827-8504
Antonio FronteraDepartament de Química, Universitat de les Illes Balears, 07122 Palma de Mallorca, Spain.ORCID 0000-0001-7840-2139
Valentine G NenajdenkoDepartment of Chemistry, M.V. Lomonosov Moscow State University, 1 Leninskie Gory, 119991 Moscow, Russia.ORCID 0000-0001-9162-5169
Andreii S KritchenkovResearch Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-6411-5988
Alexander G TskhovrebovResearch Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.

Funding

Russian Science Foundation 22-73-10007
6 · The paper itself

Abstract

In this study, we report the first example of acyclic (amino)(N-pyridinium)carbenoid gold(III) complexes synthesized via a coupling reaction between 2-pyridylselenyl chloride and Au(I)-bound isonitriles. The reaction involves an initial oxidative addition of the Se-Cl moiety to Au(I), followed by the nucleophilic addition of the pyridine fragment to the isonitrile's C≡N bond, furnishing a metallacycle. Importantly, this is the first example of the pyridine acting as a nucleophile towards metal-bound isonitriles. Arguably, such an addition is due to the chelate effect. The structures of the gold(III) carbenoid complexes were unambiguously established using X-ray diffraction and NMR spectroscopy. Theoretical calculations, including DFT, Natural Resonance Theory (NRT), and Meyer bond order (MBO) analyses, were used to analyze the different resonance forms. The reaction mechanism was further elucidated using DFT calculations, which identified the oxidative addition as the rate-determining step with a barrier of 29.7 kcal/mol. The nucleophilic addition proceeds with a minimal barrier, making the reaction highly favorable. The antiproliferative activity of new compounds

Indexed as

Antineoplastic AgentsCoordination ComplexesGoldNitrilesPyridinesPyridinium CompoundsCell Line, TumorCell ProliferationDensity Functional TheoryHumansMolecular StructureAntineoplastic AgentsCoordination ComplexesGoldNitrilesPyridinesPyridinium Compoundscarbeneschalcogen bondinggoldhalogen bondingisonitrilesnon-covalent interactionsselenazoles

Identifiers

PMID39859198
PMCPMC11765275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.