Evidence map›Paper›PMID 39859189›Full record

ArticleInternational journal of molecular sciences2025

Targeting Metabolic and Epigenetic Vulnerabilities in Glioblastoma with SN-38 and Rabusertib Combination Therapy.

Jennifer Chiou, Valeria Impedovo, Yen Bao Huynh, Ruggiero Gorgoglione, Luiz O F Penalva, Alessia Lodi, Andrew J Brenner, Stefano Tiziani

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Specific FbioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer ChiouDepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.
Valeria ImpedovoDepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-2166-4303
Yen Bao HuynhDepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0009-0008-7575-6802
Ruggiero GorgoglioneDepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-9860-0914
Luiz O F PenalvaChildren's Cancer Research Institute, UT Health San Antonio, San Antonio, TX 78229, USA.
Alessia LodiDepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.
Andrew J BrennerMays Cancer Center, UT Health San Antonio, 7979 Wurzbach Road, San Antonio, TX 78229, USA.
Stefano TizianiDepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-7230-0307

Funding

METAvivor Metastatic Translational Research Award METAvivor Metastatic Translational Research Award
6 · The paper itself

Abstract

Glioblastoma (GBM), the most prevalent primary malignant brain tumor, remains challenging to treat due to extensive inter- and intra-tumor heterogeneity. This variability demands combination treatments to improve therapeutic outcomes. A significant obstacle in treating GBM is the expression of O

Indexed as

Brain NeoplasmsGlioblastomaIrinotecanProtein Kinase InhibitorsTopoisomerase I InhibitorsAntineoplastic Combined Chemotherapy ProtocolsCell Line, TumorCheckpoint Kinase 1DNA RepairDrug Screening Assays, AntitumorDrug SynergismEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyO(6)-Methylguanine-DNA MethyltransferaseCheckpoint Kinase 1IrinotecanLY2603618O(6)-Methylguanine-DNA MethyltransferasePhenylurea CompoundsProtein Kinase InhibitorsPyrazinesTopoisomerase I Inhibitorsepigeneticsglioblastomahigh-throughput drug screeningliquid chromatography–high resolution tandem mass spectrometrymetabolomicsrabusertibSN-38subcellular metabolism

Identifiers

PMID39859189
PMCPMC11764980

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.