Potentiation of Gelonin Cytotoxicity by Pulsed Electric Fields.

Olga N Pakhomova, Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, Andrei G Pakhomov

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olga N PakhomovaFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA.ORCID 0000-0003-4950-4130

Eleni ZivlaFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA.ORCID 0009-0006-8465-6817

Giedre SilkunieneFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA.ORCID 0000-0001-8436-9718

Mantas SilkunasFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA.ORCID 0000-0002-4568-9265

Andrei G PakhomovFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA.ORCID 0000-0003-3816-3860

Funding

Pam and Rich Nuccitelli Foundation n/a

6 · The paper itself

Abstract

Gelonin is a ribosome-inactivating protein with extreme intracellular toxicity but poor permeation into cells. Targeted disruption of cell membranes to facilitate gelonin entry is explored for cancer and tissue ablation. We demonstrate a hundreds- to thousands-fold enhancement of gelonin cytotoxicity by pulsed electric fields in the T24, U-87, and CT26 cell lines. The effective gelonin concentration to kill 50% of cells (EC

Indexed as

ElectricityElectroporationRibosome Inactivating Proteins, Type 1AnimalsCell Line, TumorCell SurvivalHumansGEL protein, Gelonium multiflorumRibosome Inactivating Proteins, Type 1cancer ablationelectrochemotherapyelectropermeabilizationelectroporationirreversible electroporationpulsed field ablation

Identifiers

PMID39859180

DOI10.3390/ijms26020458

PMCPMC11764505

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.