Evidence map›Paper›PMID 39858981›Full record

ArticleMicroorganisms2025

Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients.

Piotr Czupryna, Sambor Grygorczuk, Agnieszka Siemieniako-Werszko, Jakub Okrzeja, Justyna Dunaj-Małyszko, Justyna Adamczuk, Sławomir Pancewicz, Joanna Zajkowska, Karolina Narejko, Joanna Oklińska and 2 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Piotr CzuprynaDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0000-0002-0072-2180
Sambor GrygorczukDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0000-0002-8462-3285
Agnieszka Siemieniako-WerszkoDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.
Jakub OkrzejaDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.
Justyna Dunaj-MałyszkoDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.
Justyna AdamczukDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0000-0001-5086-0285
Sławomir PancewiczDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.
Joanna ZajkowskaDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0000-0002-5695-1652
Karolina NarejkoDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.
Joanna OklińskaDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0009-0001-5779-0539
Gabriela TrojanDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.ORCID 0009-0006-1041-5500
Anna Moniuszko-MalinowskaDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.

Funding

National Science Center 2018/31/B/NZ6/02744
6 · The paper itself

Abstract

The aim of this study was to evaluate the usefulness of IgM anti-Tick-Borne Encephalitis (anti-TBE) intrathecal synthesis in the diagnosis and prediction of the clinical course of the disease. Thirty-six patients were included in the study (patients reported symptoms such as fever, headache, fatigue, and nausea/vomiting). CRP, White Blood Cells (WBC), pleocytosis, Cerebrospinal Fluid (CSF) protein concentration, CSF albumin concentration, serum IgM, serum IgG, CSF IgM, CSF IgG, IgM Index, IgG Index, and IgG Index/IgM Index ratio were the parameters which were examined in the individuals. An analysis of correlation presented statistical significance between IgM Index and pleocytosis and protein concentration in CSF in the whole group of individuals. IgM Index and IgG Index/IgM Index ratio may be used in the prediction of severity of TBE. The most probable link between the IgM intrathecal production and severity of TBE may be a result of delayed seroconversion to IgG, and therefore not an adequate response to the virus presence.

Indexed as

CSFIgMintrathecal synthesisTBEtick-borne encephalitis

Identifiers

PMID39858981
PMCPMC11767730

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.