Evidence map›Paper›PMID 39858970›Full record

ArticleMicroorganisms2025

Efflux Pumps and Porins Enhance Bacterial Tolerance to Phenolic Compounds by Inhibiting Hydroxyl Radical Generation.

Xinyue Sui, Likun Guo, Zixian Bao, Mo Xian, Guang Zhao

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Dual Mutations inInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyue SuiState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong University, Qingdao 266237, China.
Likun GuoState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong University, Qingdao 266237, China.
Zixian BaoState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong University, Qingdao 266237, China.
Mo XianCAS Key Lab of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Guang ZhaoState Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong University, Qingdao 266237, China.ORCID 0000-0003-0002-5972

Funding

National Key Research and Development Program of China 2022YFC2104700National Natural Science Foundation of China 32170085National Natural Science Foundation of China 32370068Qingdao Natural Science Foundation 23-2-1-170-zyyd-jchSKLMT Frontiers and Challenges Project SKLMTFCP-2023-03the Taishan Scholars Program tstp20231208
6 · The paper itself

Abstract

Phenolic compounds are industrially versatile chemicals that have been successfully produced in microbial cell factories. Unfortunately, most phenolic compounds are highly toxic to cells in specific cellular environments or above a particular concentration because they form a complex with iron and promote hydroxyl radical production in Fenton reactions, resulting in the ferroptosis of cells. Here, we demonstrated that overexpression of efflux pumps and porins, including porins LamB and OmpN, and efflux pumps EmrAB, MdtABC, and SrpB, can enhance

Indexed as

efflux pumpshydroxyl radicalphenolic compoundsphloroglucinolporinstoxicity

Identifiers

PMID39858970
PMCPMC11767505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.