Evidence map›Paper›PMID 39858956›Full record

ArticleMicroorganisms2025

Vaginal Dysbiosis in Infertility: A Comparative Analysis Between Women with Primary and Secondary Infertility.

Iliana Alejandra Cortés-Ortíz, Gustavo Acosta-Altamirano, Rafael Nambo-Venegas, Jesús Alejandro Pineda-Migranas, Oscar Giovanni Ríos-Hernández, Eduardo García-Moncada, Alejandra Yareth Bonilla-Cortés, Mónica Sierra-Martínez, Juan Carlos Bravata-Alcántara

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Iliana Alejandra Cortés-OrtízLaboratorio de Genética y Diagnóstico Molecular, Hospital Juárez de México, Instituto Politécnico Nacional, 5160, Col. Magdalena de las Salinas, Ciudad de México 07760, Mexico.ORCID 0000-0001-9409-5896
Gustavo Acosta-AltamiranoHospital General de México, Eje 2A Sur (Dr. Balmis) No.148, Cuauhtémoc, Doctores, Ciudad de México 06726, Mexico.
Rafael Nambo-VenegasLaboratorio de Genómica del Envejecimiento, Centro de Investigación sobre Envejecimiento (CIE-CINVESTAV Sede Sur), Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México 14330, Mexico.ORCID 0000-0003-1796-1433
Jesús Alejandro Pineda-MigranasLaboratorio de Genética y Diagnóstico Molecular, Hospital Juárez de México, Instituto Politécnico Nacional, 5160, Col. Magdalena de las Salinas, Ciudad de México 07760, Mexico.ORCID 0009-0002-6498-6684
Oscar Giovanni Ríos-HernándezLaboratorio de Genética y Diagnóstico Molecular, Hospital Juárez de México, Instituto Politécnico Nacional, 5160, Col. Magdalena de las Salinas, Ciudad de México 07760, Mexico.ORCID 0009-0008-2681-5773
Eduardo García-MoncadaLaboratorio de Genética y Diagnóstico Molecular, Hospital Juárez de México, Instituto Politécnico Nacional, 5160, Col. Magdalena de las Salinas, Ciudad de México 07760, Mexico.ORCID 0000-0001-9817-6183
Alejandra Yareth Bonilla-CortésEscuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Av. Guillermo Massieu Helguera 239, La Purísima Ticomán, Gustavo A. Madero, Ciudad de México 07320, Mexico.ORCID 0000-0003-3928-8438
Mónica Sierra-MartínezUnidad de Investigación en Salud, Hospital de Alta Especialidad Ixtapaluca, IMSS-Bienestar, Carr Federal México-Puebla Km 34.5, Ixtapaluca 56530, Mexico.ORCID 0000-0002-1006-592X
Juan Carlos Bravata-AlcántaraUnidad de Investigación en Salud, Hospital de Alta Especialidad Ixtapaluca, IMSS-Bienestar, Carr Federal México-Puebla Km 34.5, Ixtapaluca 56530, Mexico.ORCID 0000-0002-3585-0051

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility, both primary and secondary, is strongly influenced by microbiological factors, with the vaginal microbiota playing a key role in reproductive health.

objectiveThe aim of this study was to characterize the vaginal microbiota of 136 Mexican women diagnosed with infertility-primary (n = 58) and secondary (n = 78)-by evaluating the presence of pathogenic bacterial species and their associations with infertility conditions.

methodsSamples were obtained through cervical swabs, and microorganism identification was performed using qPCR techniques.

resultsAnalysis revealed a positive correlation between increased age and the likelihood of primary infertility, as well as a negative correlation with secondary infertility. Significant differences in microbial composition were also observed between the two infertility groups.

conclusionOur findings suggest that the composition of the vaginal microbiota may play a decisive role in infertility, highlighting the need for personalized therapeutic strategies based on microbial profiles.

Indexed as

HPVinfertilityvaginal microbiota

Identifiers

PMID39858956
PMCPMC11767898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.