Evidence map›Paper›PMID 39858630›Full record

ArticleGenes2025

Identifying Genetic Predisposition to Dozer Lamb Syndrome: A Semi-Lethal Muscle Weakness Disease in Sheep.

Morgan R Stegemiller, Margaret A Highland, Kathleen M Ewert, Holly Neaton, David S Biller, Brenda M Murdoch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Morgan R StegemillerDepartment of Animal, Veterinary and Food Science, University of Idaho, Moscow, ID 83844, USA.
Margaret A HighlandWI Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, WI 54812, USA.
Kathleen M EwertNotkwyta Ranch, Inc., McLouth, KS 66054, USA.
Holly NeatonNeaton Polypays, Watertown, MN 55388, USA.
David S BillerDepartment of Clinical Sciences, Kanas State University, Manhattan, KS 66506, USA.
Brenda M MurdochDepartment of Animal, Veterinary and Food Science, University of Idaho, Moscow, ID 83844, USA.ORCID 0000-0001-8675-3473

Funding

Hatch-Multistate "Increased Efficiency of Sheep Production" 1025808Idaho Global Entrepreneurial Mission 004727
6 · The paper itself

Abstract

backgroundLamb health is crucial for producers; however, the percentage of lambs that die before weaning is still 15-20%. One factor that can contribute to lamb deaths is congenital diseases. A novel semi-lethal disease has been identified in newborn Polypay lambs and termed dozer lamb syndrome. This study aims to determine if there is a genetic predisposition to dozer lamb syndrome. These lambs are weak and unable to lift their heads, suckle, and swallow, resulting in nasal reflux.

methodsGenetic analyses, including a genome-wide association, runs of homozygosity, and fine mapping to determine haploblock within regions of interest, were utilized in determining genetic predispositions to dozer lamb syndrome.

resultsThe genome-wide association study identified a region of chromosome 15 with three significant SNPs (

conclusionsThe most significant and promising gene in this region is

Indexed as

Genetic Predisposition to DiseaseMuscle WeaknessSheep DiseasesAnimalsChromosome MappingGenome-Wide Association StudyPolymorphism, Single NucleotideSheepCELF1dozer lamb syndromeGWASWGS

Identifiers

PMID39858630
PMCPMC11764822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.