Evidence map›Paper›PMID 39858606›Full record

ReviewGenes2025

Recent Advances in Stroke Genetics-Unraveling the Complexity of Cerebral Infarction: A Brief Review.

Takeshi Yoshimoto, Hiroshi Yamagami, Yuji Matsumaru

Abstract readReview
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Genes · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Takeshi YoshimotoDepartment of Stroke and Cerebrovascular Diseases, University of Tsukuba Hospital, Tsukuba 305-8576, Japan.ORCID 0000-0003-3178-8171
Hiroshi YamagamiDivision of Stroke Prevention and Treatment, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Yuji MatsumaruDepartment of Stroke and Cerebrovascular Diseases, University of Tsukuba Hospital, Tsukuba 305-8576, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesRecent advances in stroke genetics have substantially enhanced our understanding of the complex genetic architecture underlying cerebral infarction and other stroke subtypes. As knowledge in this field expands, healthcare providers must remain informed about these latest developments. This review aims to provide a comprehensive overview of recent advances in stroke genetics, with a focus on cerebral infarction, and discuss their potential impact on patient care and future research directions.

methodsWe reviewed recent literature about advances in stroke genetics, focusing on cerebral infarction, and discussed their potential impact on patient care and future research directions. Key developments include the identification of monogenic stroke syndromes, such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, and cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy caused by mutations in the

conclusionsThese genetic discoveries have important clinical implications, including improved risk stratification, targeted prevention strategies, and the development of novel therapeutic approaches.

Indexed as

Cerebral InfarctionGenetic Predisposition to DiseaseStrokeAdenosine TriphosphatasesCADASILHigh-Temperature Requirement A Serine Peptidase 1HumansMutationReceptor, Notch3Ubiquitin-Protein LigasesAdenosine TriphosphatasesHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanNOTCH3 protein, humanReceptor, Notch3RNF213 protein, humanUbiquitin-Protein Ligasesepigeneticspharmacogenomicspolygenic risk scoreRNF213-related vasculopathystroke genetics

Identifiers

PMID39858606
PMCPMC11764629

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.