ArticleGenes2024
Metallothionein-1A (MT1A) Gene Variability May Play a Role in Female Frailty: A Preliminary Study.
Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Frailty as a predictor of mortality in lung cancer survivors: evidence from a nationally representative cohort NHIS 1997-2018.Scientific reports · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND/
objectivesFrailty is a complex geriatric syndrome resulting in decreased physiological reserve. While genetics plays a role, the underlying mechanisms remain unsolved. Metallothioneins (MTs), metal-binding proteins with high affinity for zinc, an essential mineral for many physiological functions, are involved in processes including oxidative stress and inflammation. We investigated the impact of genetic variations in MTs on frailty.
methods448 subjects (235 females and 213 males, median age of 76 years) were categorized into three frailty groups (non-frail/pre-frail/frail), by hierarchical cluster analysis based on cognitive status (MMSE), functional capacity (ADL), and physical strength (HGS). Subjects were analyzed for selected SNPs in
resultsAn association was found between the rs8052394-A/G (Lys51Arg) polymorphism in the
conclusionsAlthough its associations do not survive Bonferroni correction, this exploratory study suggests a sex-specific influence of
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