Evidence map›Paper›PMID 39858554›Full record

SynthesisGenes2024

Utilization of RT-PCR and Optical Genome Mapping in Acute Promyelocytic Leukemia with Cryptic

Giby V George, Murad Elsadawi, Andrew G Evans, Sarmad Ali, Bin Zhang, M Anwar Iqbal

Abstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Uncovering theGenes · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Giby V GeorgeDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0009-0007-9529-4564
Murad ElsadawiDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-0958-4589
Andrew G EvansDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Sarmad AliDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0009-0001-2372-3426
Bin ZhangDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
M Anwar IqbalDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute promyelocytic leukemia (APL) is characterized by abnormal promyelocytes and t(15;17)(q24;q21)

methodsWe present the case of a 36-year-old male who presented with features concerning for disseminated intravascular coagulation. Although the initial diagnostic work-up, including pathology and flow cytometry evaluation, suggested a diagnosis of APL, karyotype and fluorescence in situ hybridization (FISH), using the

resultsRT-PCR revealed a cryptic

conclusionsThis case, in conjunction with the results of our systematic literature review, highlights the importance of performing confirmatory testing in FISH-negative cases of suspected APL to enable prompt diagnosis and appropriate treatment.

Indexed as

Leukemia, Promyelocytic, AcuteOncogene Proteins, FusionPromyelocytic Leukemia ProteinRetinoic Acid Receptor alphaAdultChromosome MappingGene RearrangementHumansIn Situ Hybridization, FluorescenceMaleTranslocation, GeneticOncogene Proteins, FusionPML protein, humanPromyelocytic Leukemia Proteinpromyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinRARA protein, humanRetinoic Acid Receptor alphaacute promyelocytic leukemiaAPLcryptic APLcryptic PML::RARA

Identifiers

PMID39858554
PMCPMC11765422

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.