Evidence map›Paper›PMID 39858477›Full record

ArticleBiomolecules2025

Circulating, Extracellular Vesicle-Associated Tissue Factor in Cancer Patients with and without Venous Thromboembolism.

Valentina Lami, Dario Nieri, Marta Pagnini, Mario Gattini, Claudia Donati, Mariella De Santis, Alessandro Cipriano, Erica Bazzan, Andrea Sbrana, Alessandro Celi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Valentina LamiUO Medicina d'Urgenza e Pronto Soccorso, Azienda Ospedaliero-Universitaria Pisana, 56124 Pisa, Italy.
Dario NieriUO Pneumologia, Azienda Ospedaliero-Universitaria Pisana, 56124 Pisa, Italy.ORCID 0000-0003-2971-6275
Marta PagniniDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, University of Pisa, 56126 Pisa, Italy.
Mario GattiniDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, University of Pisa, 56126 Pisa, Italy.
Claudia DonatiDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, University of Pisa, 56126 Pisa, Italy.
Mariella De SantisDipartimento Cardio Toraco Vascolare, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Alessandro CiprianoUO Medicina d'Urgenza e Pronto Soccorso, Azienda Ospedaliero-Universitaria Pisana, 56124 Pisa, Italy.ORCID 0000-0001-7085-3621
Erica BazzanDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35122 Padova, Italy.ORCID 0000-0003-2956-0880
Andrea SbranaDipartimento di Oncologia, Azienda Ospedaliero-Universitaria Pisana, 56124 Pisa, Italy.ORCID 0000-0003-4460-5282
Alessandro CeliUO Pneumologia, Azienda Ospedaliero-Universitaria Pisana, 56124 Pisa, Italy.ORCID 0000-0002-1364-9568
Tommaso NeriDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7289-1522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is characterized by chronic inflammation and hypercoagulability, with an excess of venous thromboembolism (VTE). Tissue factor, the initiator of blood coagulation, circulates associated with extracellular vesicles (EV-TF). Studies investigating EV-TF between cancer-associated and non-cancer-associated VTE are lacking. We therefore compared EV-TF in unprovoked VTE (U-VTE), cancer-associated VTE (C-VTE), and cancer without VTE (C-w/o VTE). We also investigated interleukin-6 (IL-6) levels between the same groups. The final population included 68 patients (U-VTE:

Indexed as

Extracellular VesiclesNeoplasmsThromboplastinVenous ThromboembolismAdultAgedBlood CoagulationFemaleHumansInterleukin-6MaleMiddle AgedIL6 protein, humanInterleukin-6Thromboplastincancerextracellular vesiclesthromboembolismtissue factor

Identifiers

PMID39858477
PMCPMC11762650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.