Evidence map›Paper›PMID 39858473›Full record

ArticleBiomolecules2025

PRDM16 Enhances Osteoblastogenic RUNX2 via Canonical WNT10b/β-CATENIN Pathway in Testosterone-Treated Hypogonadal Men.

Siresha Bathina, Mia Prado, Virginia Fuenmayor Lopez, Georgia Colleluori, Lina Aguirre, Rui Chen, Dennis T Villareal, Reina Armamento-Villareal

Registry-linked trialAbstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03887936 (Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03887936 phase4completednot on this map

Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2019 to 2025Enrolled92ConditionsType 2 Diabetes Mellitus, HypogonadismArmsTestosterone gel 1.62%, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siresha BathinaDivision of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1092-5600
Mia PradoDivision of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.
Virginia Fuenmayor LopezDivision of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.
Georgia ColleluoriDivision of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-4908-9873
Lina AguirreDepartment of Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87107, USA.
Rui ChenDivision of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.
Dennis T VillarealDivision of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.
Reina Armamento-VillarealDivision of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-5956-4922

Funding

Aromatase Inhibitors and Weight Loss in Severely Obese Men with HypogonadismR01HD093047 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI VILLAREAL, REINA C · 2017 to 2022
$1.9M
CSRD VA I01 CX000424CSRD VA I01 CX001665MIH NCT01378299NICHD NIH HHS R01 HD093047
6 · The paper itself

Abstract

We previously reported that

Indexed as

beta CateninCore Binding Factor Alpha 1 SubunitDNA-Binding ProteinsHypogonadismTestosteroneTranscription FactorsWnt ProteinsAdultHumansMaleMiddle AgedOsteoblastsOsteogenesisProto-Oncogene ProteinsSignal Transductionbeta CateninCore Binding Factor Alpha 1 SubunitDNA-Binding ProteinsPRDM16 protein, humanProto-Oncogene ProteinsRUNX2 protein, humanTestosteroneTranscription FactorsWNT10B protein, humanWnt ProteinsBMDosteoblastogenesisPRDM16RUNX2

Identifiers

PMID39858473
PMCPMC11764227

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.