Evidence map›Paper›PMID 39858466›Full record

ArticleBiomolecules2025

The Proapoptotic Effect of MB-653 Is Associated with the Modulation of Metastasis and Invasiveness-Related Signalling Pathways in Human Colorectal Cancer Cells.

Libor Sokoli, Peter Takáč, Mariana Budovská, Radka Michalková, Martin Kello, Natália Nosálová, Ľudmila Balážová, Šimon Salanci, Ján Mojžiš

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Libor SokoliDepartment of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovakia.
Peter TakáčDepartment of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovakia.
Mariana BudovskáDepartment of Organic Chemistry, Institute of Chemistry, Faculty of Science, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.ORCID 0000-0003-0544-1289
Radka MichalkováDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.ORCID 0000-0002-9987-1556
Martin KelloDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.ORCID 0000-0002-2454-5799
Natália NosálováSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovakia.ORCID 0000-0002-2149-5693
Ľudmila BalážováDepartment of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovakia.
Šimon SalanciDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.
Ján MojžišDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.ORCID 0000-0002-7974-4525

Funding

EDRF ITMS2014 + 313011D103EDRF ITMS2014+: 313011V455Ministry of the Education, Science, Research and Sport of the Slovak Republic VEGA 1/0074/24Ministry of the Education, Science, Research and Sport of the Slovak Republic VEGA 1/0539/21Ministry of the Education, Science, Research and Sport of the Slovak Republic VEGA 2/0112/22
6 · The paper itself

Abstract

Colorectal cancer is one of the most common cancers worldwide and has a high mortality rate. In this study, we investigated the cytotoxic, proapoptotic, and anti-invasive effects of the synthetic indole phytoalexin MB-653. The antiproliferative effect was determined using an MTT assay, showing IC

Indexed as

ApoptosisColorectal NeoplasmsIndolesSesquiterpenesSignal TransductionCaco-2 CellsCell MovementCell ProliferationEpithelial-Mesenchymal TransitionG2 Phase Cell Cycle CheckpointsHCT116 CellsHumansNeoplasm InvasivenessNeoplasm MetastasisIndolesSesquiterpenesapoptosiscolorectal cancerEMTindole phytoalexinsmetastasis

Identifiers

PMID39858466
PMCPMC11762530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.