Evidence map›Paper›PMID 39858458›Full record

ArticleBiomolecules2025

SNP rs9364554 Modulates Androgen Receptor Binding and Drug Response in Prostate Cancer.

Yuqian Yan, Lei Shi, Tao Ma, Liguo Wang, Haojie Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuqian YanDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.ORCID 0000-0002-1646-7276
Lei ShiDepartment of Radiation Oncology, Cancer Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 310025, China.
Tao MaDivision of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Liguo WangDivision of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.ORCID 0000-0003-2072-4826
Haojie HuangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS) N/A
6 · The paper itself

Abstract

(1) Background: Prostate cancer treatment efficacy is significantly influenced by androgen receptor (AR) signaling pathways. SLC22A3, a membrane transporter, has been linked to SNP rs9364554 risk loci for drug efficacy in prostate cancer. (2) Methods: We examined the location of SNP rs9364554 in the genome and utilized TCGA and other publicly available datasets to analyze the association of this SNP with

Indexed as

Organic Cation Transport ProteinsPolymorphism, Single NucleotideProstatic NeoplasmsReceptors, AndrogenCell Line, TumorDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-alphaHumansMaleOrganic Cation Transporter 3Promoter Regions, GeneticProtein BindingAR protein, humanFOXA1 protein, humanHepatocyte Nuclear Factor 3-alphaOrganic Cation Transporter 3Organic Cation Transport ProteinsReceptors, AndrogenARdrug efficacyFOXA1prostate cancerSLC22A3SNP rs9364554

Identifiers

PMID39858458
PMCPMC11763896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.