Evidence map›Paper›PMID 39858451›Full record

ArticleBiomolecules2025

Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes.

Murali Ganesan, Anup S Pathania, Grace Bybee, Kusum K Kharbanda, Larisa Y Poluektova, Natalia A Osna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [Advancement in the role of exosomes for hepatitis B virus infection diagnosis and treatment: mechanisms and clinical applications].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  2. Review
  3. Virus infection and vesicle trafficking.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Murali GanesanDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Anup S PathaniaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-1517-2919
Grace BybeeDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kusum K KharbandaDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA.ORCID 0000-0001-7759-8889
Larisa Y PoluektovaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-7339-8732
Natalia A OsnaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-7498-0556

Funding

The Role of TP-R on Alcohol-Induced Multi-Organ Damage: Liver and HeartP50AA030407 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Carol A. Casey · 2023 to 2026
$7.9M
New generation of long acting nucleos(t)ides and immune stimulant for treatment of chronic hepatitis BR01AI163042 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Benson Edagwa, NATALIA ALEKSANDR OSNA · 2022 to 2026
$3.1M
BLRD VA I01 BX006064NIAAA NIH HHS P50 AA030407NIAID NIH HHS R01 AI163042NIH (NIAAA) P50AA030407-5129
6 · The paper itself

Abstract

About 296 million people worldwide are living with chronic hepatitis B viral (HBV) infection, and outcomes to end-stage liver diseases are potentiated by alcohol. HBV replicates in hepatocytes, but other liver non-parenchymal cells can sense the virus. In this study, we aimed to investigate the regulatory effects of macrophages on HBV marker and interferon-stimulated genes (ISGs) expressions in hepatocytes. This study was performed on HBV-replicating HepG2.2.15 cells and human monocyte-derived macrophages (MDMs). We found that exposure of HepG2.2.15 cells to an acetaldehyde-generating system (AGS) increased HBV RNA, HBV DNA, and cccDNA expressions and suppressed the activation of ISGs,

Indexed as

EthanolHepatitis B virusHepatocytesMacrophagesExosomesHep G2 CellsHumansInterferon-alphaVirus ReplicationEthanolInterferon-alphaethanolHBVhepatocytesinterferon-stimulated genesmacrophages

Identifiers

PMID39858451
PMCPMC11761873

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.