Evidence map›Paper›PMID 39858424›Full record

ArticleBiomolecules2024

Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer's Disease.

Marilena K Theodoropoulou, Konstantina D Vraila, Nikos C Papandreou, Georgia I Nasi, Vassiliki A Iconomidou

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marilena K TheodoropoulouSection of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 01 Athens, Greece.ORCID 0000-0001-8814-0750
Konstantina D VrailaSection of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 01 Athens, Greece.ORCID 0009-0000-7799-0653
Nikos C PapandreouSection of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 01 Athens, Greece.ORCID 0000-0002-3533-2182
Georgia I NasiSection of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 01 Athens, Greece.ORCID 0000-0002-4988-7066
Vassiliki A IconomidouSection of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 01 Athens, Greece.ORCID 0000-0002-9472-5146

Funding

Operational Program "Competitiveness, Entrepreneurship and Innovation", under the call "RE-SEARCH-CREATE-INNOVATE" T1EDK-00353
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by extracellular amyloid plaques, predominantly consisting of amyloid-

Indexed as

Alzheimer DiseaseCathepsin BPeptidesPlaque, AmyloidAmyloid beta-PeptidesHumansMolecular Docking SimulationMolecular Dynamics SimulationAmyloid beta-PeptidesCathepsin BPeptidesaggregation-prone regionsAlzheimer’s diseaseamyloid-βAβCathepsin Bmolecular dynamicsumbrella sampling

Identifiers

PMID39858424
PMCPMC11762647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.