Evidence map›Paper›PMID 39858404›Full record

ArticleBiomolecules2024

Neurofilament Light Chain Levels in Serum and Cerebrospinal Fluid Do Not Correlate with Survival Times in Patients with Prion Disease.

Mika Shimamura, Kong Weijie, Toshiaki Nonaka, Koki Kosami, Ryusuke Ae, Koji Fujita, Taiki Matsubayashi, Tadashi Tsukamoto, Nobuo Sanjo, Katsuya Satoh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mika ShimamuraBiomedical Research Support Center, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.ORCID 0000-0002-3830-2173
Kong WeijieUnit of Medical and Dental Sciences, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Toshiaki NonakaDivision of Cellular and Molecular Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.ORCID 0009-0001-9914-2599
Koki KosamiDivision of Public Health, Center for Community Medicine, Jichi Medical University, Tochigi 329-0498, Japan.ORCID 0000-0003-1050-2699
Ryusuke AeDivision of Public Health, Center for Community Medicine, Jichi Medical University, Tochigi 329-0498, Japan.ORCID 0000-0003-2660-530X
Koji FujitaDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Taiki MatsubayashiDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8510, Japan.ORCID 0000-0003-0984-531X
Tadashi TsukamotoDepartment of Neurology, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
Nobuo SanjoDepartment of Internal Medicine, Division of Neurology, Kudanzaka Hospital, 1-6-12 Kudan-minami, Chiyoda-ku, Tokyo 102-0074, Japan.
Katsuya SatohUnit of Medical and Dental Sciences, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.ORCID 0000-0001-8007-8710

Funding

Japan Agency for Medical Research and Development JP18ek0109362Japan Agency for Medical Research and Development JP20ak0101151Japan Agency for Medical Research and Development JP23ek0109620MHLW Researches on Rare and Intractable Diseases Health, Labour and Welfare Policy Research JPMH20FC2002MHLW Researches on Rare and Intractable Diseases Health, Labour and Welfare Policy Research JPMH23FC1007
6 · The paper itself

Abstract

Prion diseases, including Creutzfeldt-Jakob disease (CJD), are deadly neurodegenerative disorders characterized by the buildup of abnormal prion proteins in the brain. This accumulation disrupts neuronal functions, leading to the rapid onset of psychiatric symptoms, ataxia, and cognitive decline. The urgency of timely diagnosis for effective treatment necessitates the identification of strongly correlated biomarkers in bodily fluids, which makes our research crucial. In this study, we employed a fully automated multiplex ELISA (Ella

Indexed as

Creutzfeldt-Jakob SyndromeNeurofilament ProteinsPrion Diseases14-3-3 ProteinsAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedPrognosistau Proteins14-3-3 ProteinsBiomarkersneurofilament protein LNeurofilament Proteinstau Proteinscerebrospinal fluidCreutzfeldt–Jakob diseaseneurofilament light chainprionserum

Identifiers

PMID39858404
PMCPMC11760854

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.