Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes.

Jianying Han, Xueting Liu, Lixin Zhang, Ronald J Quinn, Miaomiao Liu

Abstract read

In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Dual-Mode Native Mass Spectrometry Screening Identifies Ginsenoside Ligands of 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase (HPPK).Molecules (Basel, Switzerland) · 2026
Article
Screening of Red Sea- and Mediterranean Sea-derived Actinomycetes for Antimicrobial and Antitumor activities: LC-ESI-HRMS-based Metabolomics Study.Microbial cell factories · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianying HanInstitute for Biomedicine and Glycomics, Griffith University, Brisbane, QLD 4111, Australia.ORCID 0000-0003-4402-6598

Xueting LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.

Lixin ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.

Ronald J QuinnInstitute for Biomedicine and Glycomics, Griffith University, Brisbane, QLD 4111, Australia.ORCID 0000-0002-4022-2623

Miaomiao LiuInstitute for Biomedicine and Glycomics, Griffith University, Brisbane, QLD 4111, Australia.ORCID 0000-0003-0930-3617

Funding

National Health and Medical Research Council 2017517

6 · The paper itself

Abstract

backgroundThe increasing prevalence of drug-resistant tuberculosis (TB) underscores the urgent need for novel antimicrobial agents.

methodsThis study integrates cultivation optimization, nuclear magnetic resonance (NMR) fingerprinting, and principal component analysis (PCA) to explore microbial secondary metabolites as potential anti-TB agents.

resultsUsing the combined approach, 11 bioactive compounds were isolated and identified, all exhibiting anti-

conclusionsThese findings emphasize the value of microbial metabolites as a reservoir of bioactive compounds and provide new avenues for developing next-generation anti-TB therapies.

Indexed as

actinomycetesbafilomycinborrelidinelaiophylinpolycyclic tetramate macrolactamstuberculosis

Identifiers

PMID39858393

DOI10.3390/antibiotics14010108

PMCPMC11763000

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.