Evidence map›Paper›PMID 39858215›Full record

ArticleAnimals : an open access journal from MDPI2025

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Madison R Barshick, Kristine M Ely, Keely C Mogge, Lara M Chance, Sally E Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madison R BarshickSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.ORCID 0009-0008-1459-1151
Kristine M ElySchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.
Keely C MoggeSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.
Lara M ChanceSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.
Sally E JohnsonSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.ORCID 0000-0002-9514-4220

Funding

Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Resources and Workforce Development for the Regional Biocontainment LaboratoriesUC7AI180254 · NIAID · DUKE UNIVERSITY · PI Herman F Staats · 2023 to 2026
$14.0M
Regional Biocontainment Laboratories Facility and Building System Upgrades SupportG20AI167200 · NIAID · DUKE UNIVERSITY · PI STAATS, HERMAN F · 2021 to 2022
$6.6M
NIAID NIH HHS G20 AI167200NIAID NIH HHS UC6 AI058607NIAID NIH HHS UC7 AI180254
6 · The paper itself

Abstract

Methylsulfonylmethane (MSM) is a sulfur-containing molecule with reported anti-inflammatory and antioxidant activities. Exercise causes the formation of free radicals and stimulates inflammatory gene expression in leukocytes and skeletal muscle. The hypothesis that dietary supplementation with MSM alters the exercise-mediated inflammatory and oxidant response was assessed in unfit adult thoroughbred geldings. Ten geldings (6.7 ± 1.6 yr) were assigned to a diet supplemented without (CON,

Indexed as

cytokineequineglutathione peroxidasemethylsulfonylmethaneskeletal muscletranscriptome

Identifiers

PMID39858215
PMCPMC11758608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.