ArticleAnimals : an open access journal from MDPI2025
Validation of a Portable Ionized Calcium Detection Device and Changes in the Ionized-to-Total-Calcium Ratio in the Blood of Postpartum Holstein Cows.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Reticuloruminal Motility Monitoring for the Prediction of Peripartal Hypocalcemia in Cattle.Animals : an open access journal from MDPI · 2025Article
- A simple, inexpensive, and rapid method for measuring calcium concentrations in colostrum to predict postpartum milk fever in cows using a commercially available water quality test device.The Journal of veterinary medical science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The calcium requirements of dairy cows increase dramatically soon after calving, and many cows have subclinical hypocalcemia, adversely affecting health and performance. Traditional laboratory tests for calcium are complex and not easily adapted to rapid point-of-care applications. The objectives were to evaluate a portable iCa testing device, Horiba LAQUAtwin Ca-11C, for measuring ionized calcium (iCa) in the whole blood of dairy cows and to investigate the iCa-to-total-calcium (tCa) ratio in blood collected from dairy cows within 9 days after calving. This study was conducted on two large dairies in northern China. First, blood samples were collected from 246 cows within 3 days after calving, and whole-blood iCa concentrations were measured with a Horiba LAQUAtwin Ca-11C and Abbott i-STAT 1. In addition, 885 blood samples were collected from 102 dairy cows between calving and 9 days postpartum, with iCa concentrations measured using a Horiba LAQUAtwin Ca-11C and tCa concentrations determined by a fully automated biochemical analyzer. The Horiba LAQUAtwin Ca-11C and Abbott i-STAT 1 had significant consistency in the measurement of ionized calcium concentration in whole blood (the frequency of differences between the measured values was within ±20% of the average, reaching 95.53%), and the measurement results of the two instruments were correlated (Deming regression analysis R
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Registered trials
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