Evidence map›Paper›PMID 39858058›Full record

ArticleCancers2025

Targeting the MDM2-p53 Interaction with Siremadlin: A Promising Therapeutic Strategy for Treating

Erhan Aptullahoglu, Mohammed Howladar, Jonathan P Wallis, Helen Marr, Scott Marshall, Julie Irving, Elaine Willmore, John Lunec

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erhan AptullahogluBiosciences Institute & Newcastle University Cancer Centre, Medical Faculty, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-9400-0938
Mohammed HowladarBiosciences Institute & Newcastle University Cancer Centre, Medical Faculty, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Jonathan P WallisDepartment of Haematology, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK.
Helen MarrDepartment of Haematology, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK.
Scott MarshallDepartment of Haematology, City Hospitals Sunderland NHS Trust, Sunderland SR4 7TP, UK.
Julie IrvingBiosciences Institute & Newcastle University Cancer Centre, Medical Faculty, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Elaine WillmoreBiosciences Institute & Newcastle University Cancer Centre, Medical Faculty, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-4762-094X
John LunecBiosciences Institute & Newcastle University Cancer Centre, Medical Faculty, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-1878-8583

Funding

Blood Cancer UK 13034Cancer Research UK C2215/A21421JGW Paterson Foundation BH152495Newcastle Healthcare Charity BH152694
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chronic lymphocytic leukemia (CLL)MDM2-p53 antagonistsp53p53-dependent apoptosissiremadlin (HDM201)

Identifiers

PMID39858058
PMCPMC11763703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.