Evidence map›Paper›PMID 39858003›Full record

ReviewCancers2025

A Multidisciplinary Approach to Diagnosing Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Practical Recommendations and Insights from Countries of the Gulf Cooperation Council.

Nasir Bakshi, Ayman Al Hejazi, Hatim Al-Maghraby, Areej Al Mugairi, Ahmad S Alotaibi, Haitham Khogeer, Rania Medhat Seliem, Ramesh Pandita, Heba Raslan, Phyu P Aung and 1 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nasir BakshiDepartment of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 12713, Saudi Arabia.
Ayman Al HejaziDepartment of Oncology, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh 11426, Saudi Arabia.
Hatim Al-MaghrabyDepartment of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Madinah 42522, Saudi Arabia.
Areej Al MugairiHematopathology Division, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh 14611, Saudi Arabia.
Ahmad S AlotaibiOncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 12713, Saudi Arabia.ORCID 0000-0003-4662-8787
Haitham KhogeerDepartment of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 12713, Saudi Arabia.
Rania Medhat SeliemRashid Hospital, Dubai Health Authority, Dubai P.O. Box 4545, United Arab Emirates.
Ramesh PanditaDepartment of Hematology, Kuwait Cancer Control Centre, Shuwaikh 42262, Kuwait.ORCID 0000-0003-0563-0442
Heba RaslanDepartment of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia.
Phyu P AungDepartment of Anatomic Pathology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA.ORCID 0000-0002-3398-0573
Robert S OhgamiARUP Laboratories, Department of Pathology, University of Utah, Salt Lake City, UT 84103, USA.

Funding

CSRD VA 1
6 · The paper itself

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive orphan hematopoietic malignancy characterized by cutaneous and systemic hematologic involvement. BPDCN is frequently misidentified, but early, accurate diagnosis is critical to extending patient survival using tagraxofusp, a first-in-class CD123-targeted therapy, and increasing their chances of receiving a potentially curative stem cell transplantation. Cases of BPDCN in countries of the Gulf Cooperation Council are lower than the extrapolated incidence from other geographic locations due to lack of awareness of key diagnostic features, lack of consensus on the minimal phenotype for diagnosis, and lack of local immunohistochemistry testing facilities, contributing to underdiagnosis in this region. Practical recommendations, a streamlined diagnostic panel, and suggested multidisciplinary approaches based on expert experience regarding diagnostic and clinical challenges specific to this region, and a review of the literature are presented here to facilitate diagnosis of BPDCN in this region by primary care physicians, dermatologists, and hematologists.

Indexed as

blastic plasmacytoid dendritic cell neoplasmconsensus recommendationsdendritic cells/pathologydifferential diagnosisGulf Cooperation Councilhematologic neoplasms/diagnosistagraxofusp

Identifiers

PMID39858003
PMCPMC11763774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.