Evidence map›Paper›PMID 39857437›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Multicomponent Dietary Supplementation: Impact on Tear Secretion and Ocular Surface Inflammation in Dry Eye Syndrome Patients.

Shih-Chien Huang, Yen-Ping Lei, Min-Chien Hsiao, Yu-Kai Hsieh, Quei-Ping Tang, Connie Chen, Min-Yen Hsu

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Lute-GenAntioxidants (Basel, Switzerland) · 2026
    Article
  4. Translating Biomarker Discovery: From Bench to Bedside in Dry Eye Disease.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shih-Chien HuangDepartment of Nutrition, Chung Shan Medical University, Taichung City 402, Taiwan.ORCID 0000-0001-8305-9160
Yen-Ping LeiDepartment of Nursing, National Yang Ming Chiao Tung University, Hsinchu City 300, Taiwan.
Min-Chien HsiaoDepartment of Medical Education, Changhua Christian Hospital, Changhua City 500, Taiwan.
Yu-Kai HsiehSchool of Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Quei-Ping TangDepartment of Nutrition, Wei Gong Memorial Hospital, Toufen City 351, Taiwan.
Connie ChenDepartment of Ophthalmology, Chung Shan Medical University Hospital, Taichung City 402, Taiwan.
Min-Yen HsuDepartment of Ophthalmology, Chung Shan Medical University Hospital, Taichung City 402, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry eye syndrome (DES) is a prevalent ocular condition characterized by tear film instability, inflammation, and discomfort, affecting millions worldwide. DES is related to oxidative stress imbalance and ocular surface inflammation, which are important factors in the development of the condition. Recent studies have demonstrated that fish oil, lutein, and zeaxanthin possess anti-inflammatory and antioxidant properties. This study investigated the efficacy of a multicomponent dietary supplement in improving tear secretion and mitigating ocular surface inflammation in patients with DES. It was an open-label intervention trial. In total, 52 participants were randomly assigned to control (

Indexed as

dry eye syndromefish oilinflammationluteinoxidative stresszeaxanthin

Identifiers

PMID39857437
PMCPMC11760835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.