Evidence map›Paper›PMID 39857388›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Anti-Inflammatory, Antioxidant and Antibacterial Properties of Tomato Skin and Pomegranate Peel Extracts: A Sustainable Approach for Oral Health Care.

Alessia Silla, Angela Punzo, Francesca Bonvicini, Matteo Perillo, Marco Malaguti, Antonello Lorenzini, Ismaela Foltran, Dario Mercatante, Mara Mandrioli, Maria Teresa Rodriguez-Estrada and 2 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessia SillaDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy.ORCID 0009-0002-2085-2334
Angela PunzoDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-3026-6830
Francesca BonviciniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0001-8101-9835
Matteo PerilloDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-8778-6258
Marco MalagutiDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0003-0349-7772
Antonello LorenziniDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-9615-9697
Ismaela FoltranIncos-Cosmeceutica Industriale, Funo di Argelato, 40050 Bologna, Italy.
Dario MercatanteDepartment of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, 40127 Bologna, Italy.ORCID 0000-0002-8673-2661
Mara MandrioliDepartment of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, 40127 Bologna, Italy.ORCID 0000-0003-1882-2320
Maria Teresa Rodriguez-EstradaDepartment of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, 40127 Bologna, Italy.ORCID 0000-0001-6406-4183
Silvana HreliaDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0001-7857-4512
Cristiana CalicetiDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-6740-5331

Funding

MUR-PRIN2022 Prot. 2022LW54KCPOR-FESR Emilia Romagna PG/2019/894236 CUP: E51B20000110009
6 · The paper itself

Abstract

Agricultural food waste and by-products could provide high-value compounds that positively affect human and environmental health, thus representing promising ingredients for cosmeceutical products. This study explores the biological activities of tomato skin (HP) and pomegranate peel (PPE) extracts on oral mucosa to evaluate their possible use in mouthwashes. The biological activities of the extracts and the mouthwash (MW) containing them were evaluated in Human Primary Gingival Epithelial cells (HGECs). The antioxidant and anti-inflammatory activities were analyzed in HGECs injured with lipopolysaccharides. After 24 h of treatment with PPE, HP, and MW, significant antioxidant activity and an increased Superoxide Dismutase 1 expression (

Indexed as

antibacterial activityanti-inflammatory activityantioxidant activitymouthwashoral carepomegranate peeltomato skin

Identifiers

PMID39857388
PMCPMC11762152

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.