ReviewAntioxidants (Basel, Switzerland)2024
The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants.
Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Effects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial.Journal of the International Society of Sports Nutrition · 2026Trial
- Enzyme-Specific Redox Stability and Plasticity in Trained Youth Athletes: Longitudinal Analysis of SOD and GPX.International journal of molecular sciences · 2026Article
- Curcumin's Protective Effects Against HMolecules (Basel, Switzerland) · 2026Review
- Blood Cells Far from Equilibrium: Redox Adaptation in Health and Disease.Antioxidants (Basel, Switzerland) · 2026Article
- Physiology, monitoring, and optimisation of perioperative tissue oxygenation: a narrative review.British journal of anaesthesia · 2026Review
- Tomato Polyphenols Protect Human Red Blood Cells from Mercury-Induced Oxidative Stress and Phosphatidylserine Exposure.Current issues in molecular biology · 2026Article
- Association Between Hemoglobin Glycation Index and Mortality in Critically Ill Patients With Atrial Fibrillation: A Retrospective Cohort Study.Clinical cardiology · 2026Article
- Response of Human Red Blood Cells to Acute and Chronic Oxidant Challenge as Observed Through the Glutathione and Glutathionyl-Hemoglobin Redox Pairs In Vitro and In Vivo.Molecules (Basel, Switzerland) · 2026Article
- From Circulation to Regeneration: Blood Cell Membrane-Coated Nanoparticles as Drug Delivery Platform for Immune-Regenerative Therapy.Pharmaceutics · 2026Review
- Sustained low micromolar hydrogen peroxide exposure induces sequential red blood cell dysfunction.Frontiers in physiology · 2026Article
- Synergistic Genotoxic Effects of Gamma Rays and UVB Radiation on Human Blood.Antioxidants (Basel, Switzerland) · 2025Article
- Redox Potential (EMolecules (Basel, Switzerland) · 2025Article
- Mechanistic Insights into Mancozeb-Induced Redox Imbalance and Structural Remodelling Affecting the Function of Human Red Blood Cells.Antioxidants (Basel, Switzerland) · 2025Article
- Serum Proteomics Reveals Systemic Responses inPathogens (Basel, Switzerland) · 2025Article
- Cytoprotective Potential ofInternational journal of molecular sciences · 2025Article
- Redox Homeostasis in Red Blood Cells: From Molecular Mechanisms to Antioxidant Strategies.Current issues in molecular biology · 2025Review
- Red Blood Cells and Human Aging: Exploring Their Biomarker Potential.Diagnostics (Basel, Switzerland) · 2025Review
- Atmospheric pressure plasma treatment increases the antioxidant capacity of the serum in vitro.Scientific reports · 2025Article
- The Potential of Red Blood Cells in Regenerative Medicine: A Paradigm Shift in Cellular Therapy.Cells · 2025Review
- The Role of Oxidative Stress in Ischaemic Stroke and the Influence of Gut Microbiota.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Red blood cells (RBCs) are a vital component of the body's oxygen supply system. In addition to being pro-oxidants, they are also essential components of the body's antioxidant defense mechanism. RBCs are susceptible to both endogenous and exogenous sources of oxidants. Oxyhemoglobin autoxidation is the primary source of endogenous RBC oxidant production, which produces superoxide radicals and hydrogen peroxide. Potent exogenous oxidants from other blood cells and the surrounding endothelium can also enter RBCs. Both enzymatic (like glutathione peroxidase) and non-enzymatic (like glutathione) mechanisms can neutralize oxidants. These systems are generally referred to as oxidant scavengers or antioxidants, and they work to neutralize these harmful molecules (i.e., oxidants). While their antioxidative capabilities are essential to their physiological functions and delivering oxygen to tissues, their pro-oxidant behavior plays a part in several human pathologies. The redox-related changes in RBCs can have an impact on their function and fate. The balance between pro-oxidants and antioxidants determines the oxidative status of cells, which affects signal transduction, differentiation, and proliferation. When pro-oxidant activity exceeds antioxidative capacity, oxidative stress occurs, leading to cytotoxicity. This type of stress has been linked to various pathologies, including hemolytic anemia. This review compiles the most recent literature investigating the connections between RBC redox biochemistry, antioxidants, and diverse disorders.
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Registered trials
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