Evidence map›Paper›PMID 39857303›Full record

ReviewBiology2025

7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats.

Ana Carolina Ciseski Gonçalves, Katia Candido Carvalho, José Antônio Orellana Turri, Ricardo Dos Santos Simões, Jesus Paula Carvalho, Luiz Fernando Ferraz da Silva, José Maria Soares Júnior, Edmund Chada Baracat

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana Carolina Ciseski GonçalvesFaculdade de Medicina de Bauru, Universidade de São Paulo, Bauru 17012-901, SP, Brazil.ORCID 0000-0002-1179-469X
Katia Candido CarvalhoLaboratório de Ginecologia Estrutural e Molecular (LIM 58) do Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo 17012-901, SP, Brazil.ORCID 0000-0001-7295-678X
José Antônio Orellana TurriLaboratório de Ginecologia Estrutural e Molecular (LIM 58) do Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo 17012-901, SP, Brazil.ORCID 0000-0003-2366-921X
Ricardo Dos Santos SimõesDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 17012-901, SP, Brazil.
Jesus Paula CarvalhoDisciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 17012-901, SP, Brazil.
Luiz Fernando Ferraz da SilvaDepartamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo 17012-901, SP, Brazil.ORCID 0000-0002-0181-6357
José Maria Soares JúniorLaboratório de Ginecologia Estrutural e Molecular (LIM 58) do Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo 17012-901, SP, Brazil.ORCID 0000-0003-0774-9404
Edmund Chada BaracatLaboratório de Ginecologia Estrutural e Molecular (LIM 58) do Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo 17012-901, SP, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/24224-9National Council for Scientific and Technological Development 304264/2021-0
6 · The paper itself

Abstract

Ovarian cancer has the highest mortality rate of all gynecological cancers. Animal models using 7,12-dimethylbenz(a)anthracene (DMBA) have been developed to investigate the mechanisms of ovarian carcinogenesis. The present study is a systematic review of efforts to establish DMBA as a model for ovarian cancer induction in rat models. A total of 432 studies were retrieved from the Medline/PubMed and Embase databases. The studies using DMBA to induce ovarian cancer with isolated results were included in our analysis, and their data were meta-analyzed. The ROBINS-I tool and a meta-analysis demonstrated a low risk of bias (less than 1%) for increased effectiveness and no bias for mortality. The results were all similar: regardless of the dose, administration route, animal strain, or induction time, the induction rate of ovarian tumors was always high, reinforcing the role of DMBA as an effective inducer of ovarian carcinogenesis. We conclude that ovarian carcinogenesis can be studied using DMBA as an inducer in rat and mouse models with a long time range for tumor establishment (at least 110 days) and a high rate of mortality. CNPq (No. 304264/2021-0) and FAPESP (Protocol No. 2018/24224-9).

Indexed as

animal modelDMBAovarian cancer

Identifiers

PMID39857303
PMCPMC11762512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.