Evidence map›Paper›PMID 39857264›Full record

ArticleBiology2025

NF-κB-Inducing Kinase Is Essential for Effective c-Rel Transactivation and Binding to the

Natalia Cuesta, Anna D Staniszewska, Cristóbal Moreno, Carmen Punzón, Manuel Fresno

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natalia CuestaDepartment of Cell Biology and Histology, School of Medicine, Universidad Complutense de Madrid, Avda Complutense s/n, 28040 Madrid, Spain.ORCID 0000-0003-0809-2934
Anna D StaniszewskaDepartment of Biochemistry and Molecular Biology, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas, Nicolás Cabrera 1, 28049 Madrid, Spain.ORCID 0000-0003-1328-1959
Cristóbal MorenoDepartment of Biochemistry and Molecular Biology, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas, Nicolás Cabrera 1, 28049 Madrid, Spain.
Carmen PunzónDepartment of Biochemistry and Molecular Biology, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas, Nicolás Cabrera 1, 28049 Madrid, Spain.
Manuel FresnoDepartment of Biochemistry and Molecular Biology, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas, Nicolás Cabrera 1, 28049 Madrid, Spain.

Funding

Comunidad de Madrid S2010/BMD-2332European Union FP-2003European Union LSHG-CT-2003-502935Instituto de Salud Carlos III RD06/0014/1013 Red RECAVAMinisterio de Ciencia, Innovación y Universidades SAF2007-61716Ministerio de Ciencia, Innovación y Universidades SAF2010-18733
6 · The paper itself

Abstract

This study investigates the role of NIK in activating specific inflammatory genes in macrophages, focusing on the effect of a mutation in NIK found in alymphoplasia (

Indexed as

c-RelIL-12macrophagesNIK

Identifiers

PMID39857264
PMCPMC11760456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.