ArticleLipids in health and disease2025
Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Atherogenic Index of Plasma as Predictor for Cardiovascular Events and Cardiometabolic Diseases:Findings from the PAMELA Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Metabolic disorder-MASLD-cardiovascular disease-kidney disease (MMCK) syndrome: an expansion of the Cardiovascular-Kidney-Metabolic (CKM) framework.Cardiovascular diabetology. Endocrinology reports · 2026Review
- Comparative predictive value of three non-insulin-based insulin resistance indices for subclinical left ventricular dysfunction in type 2 diabetes mellitus.BMC cardiovascular disorders · 2026Article
- Assessment of Triglyceride/High-Density Lipoprotein Cholesterol Ratio and Triglyceride-Glucose Index Threshold in Patients with Chronic Kidney Disease: Evaluation of Clinical Features and Outcomes.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Pulse Wave Velocity Progression Determinants: No Significant Association with Novel Lipids Parameter.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Serum Uric Acid in the PAMELA Study: Main Findings and Association with the Atherogenic Index of Plasma.Metabolites · 2025Review
- Exploring the synergistic effects of Life's Essential 8, insulin resistance, and CRP on cardiometabolic multimorbidity risk.Frontiers in nutrition · 2025Article
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Abstract
backgroundInsulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributes to IR, while IR is a known predictor for the development of hyperuricemia. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker for IR. This research aimed to investigate the interaction between IR and glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk in a large population cohort study.
methodsData from 18,694 subjects were analyzed from Uric acid Right foR heArt Healt (URRAH) database. The study evaluated the association between TG/HDL-C ratio and SUA/GFR ratio, as well as their impact on the development of outcomes during the follow-up study period. The primary endpoint was CV mortality.
resultsAfter a mean follow-up of 124 ± 64 months, 2,665 (14.2%) CV deaths occurred. The incidence of fatal and non-fatal CV events increased in parallel with the increase of TG/HDL-C quintiles. TG/HDL-C ratio showed a positive association with increasing of SUA/GFR ratio, even in non-diabetic patients. Multivariate analysis showed that the TG/HDL-C ratio increases the mortality risk even after adjustment for potential confounding factors. Finally, IR and GFR-adjusted hyperuricemia showed an additive effect on CV mortality.
conclusionsBoth IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. The joint effect of the TG/HDL-C ratio and the elevated SUA/GFR ratio was greater than the presence of each single risk factor on CV mortality. This highlights the importance of monitoring these markers to better assess cardiovascular risk.
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