Evidence map›Paper›PMID 39856657›Full record

ArticleBMC veterinary research2025

Study on the response mechanism of MicroRNA novel-13 and novel-44 to Vibrio parahaemolyticus infection in Pinctada fucata martensii.

Chao Jie Li, Qi Yuan Zhang, Bin Zhang, Hai Ying Liang, Li Ning Ma, Muhammad Salman

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Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Chao Jie Li *Fisheries College of Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China.
Qi Yuan Zhang *Fisheries College of Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China.
Bin ZhangFisheries College of Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China.
Hai Ying LiangFisheries College of Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China. zjlianghy@126.com.
Li Ning MaFisheries College of Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China.
Muhammad SalmanFisheries College of Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China.

Funding

Innovation Team Project from the department of Education of Guangdong Province No. 2021KCXTD026National Natural Science Foundation of China No. 31472306Natural Science Foundation of Guangdong Province No. 2023A1515012924 and No. 2021A1515010962Science and technology Special Fund of Guangdong Province 2021A05250
6 · The paper itself

Abstract

Pinctada fucata martensii (P. f. martensii) is one of the main pearl oysters cultured in artificial seawater in China. However, it is highly susceptible to pathogen infection under intensive cultivation near the coast. MicroRNAs (miRNAs), as an innovative and potent regulator of immune function, play a pivotal role in the immune response of pearl oysters to external stimuli and are a potent marker for the response of P. f. martensii to infection. This study identified two novel miRNAs, novel-13 and novel-44, from the whole transcriptome of the P. f. martensii hemocyte before and after infection with Vibrio parahaemolyticus. The dual luciferase results showed that novel-13 negatively regulated LAAO and novel-44 negatively regulated ILK. The activity of antioxidant-related enzymes increased significantly in the synthetic miRNA (novel-13 and novel-44) inhibitors and decreased significantly in the synthetic miRNA mimics. In the challenge experiment, injection with miRNA inhibitor increased the relative survival percentage by 10% compared with the control group. In conclusion, the overexpression of novel-13 and novel-44 can decrease the activity of immune and antioxidant-related enzymes, possibly affecting immune regulation in P. f. martensii by negatively regulating the LAAO and ILK target genes.

Indexed as

MicroRNAsPinctadaVibrio parahaemolyticusAnimalsHemocytesTranscriptomeVibrio InfectionsMicroRNAsmiRNAsPinctada fucata martensiiTarget geneVibrio parahaemolyticus

Identifiers

PMID39856657
PMCPMC11760096

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.