ArticleBMC pediatrics2025
Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe).
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- IL-27 neutralization with and without antibiotics as an approach to prevent and treat neonatal sepsis.JCI insight · 2026Article
- Impact of Early-Life Antibiotic Exposure on Gut Microbiome and Vaccine Immunogenicity in Infants: A Narrative Review.Journal of clinical medicine · 2026Review
- Multimodal Implementations to Reduce Neonatal Ventilator-Associated Pneumonia and Colistin Use: An Interrupted Time Series.Antibiotics (Basel, Switzerland) · 2025Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundExcessive prescription of antibiotics in infants increases the risk of short-term and lifelong morbidity and mortality. Nonetheless, the use of antibiotics in neonatal intensive care units (NICUs) is significantly high. This is primarily because neonatologists are concerned about the fragile immune systems of newborns, their vulnerability to serious infectious diseases, and the challenge of accurately distinguishing between infectious and non-infectious conditions.
methodA five-month cross-sectional prospective study was conducted in southwestern Iran's largest neonatal intensive care unit. This study aimed to evaluate the dose and duration of antibiotic therapy and identify the prescribing pattern of antibiotics based on the Access, Watch, and Reserve (AWaRe) classification recommended by the World Health Organization (WHO).
resultsOut of 502 examined patient files, antibiotics were prescribed for 483 neonates. The most common drug combinations were ampicillin and amikacin. The mean number and duration of antibiotic administration were 2.14 drugs and 7.78 days, respectively. 84.3% of infants received antibiotics for ten days or less. The mean course of antibiotic prescription for newborns was 1.1, and 83.1% of prescribed antibiotics were from the Access Group.
conclusionThe antibiotic prescription rate was high in our study's department. Most neonates received two antibiotics in one course from the Access group.
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