Evidence map›Paper›PMID 39856541›Full record

Trial reportBMC anesthesiology2025

Up-and-down determination of prophylactic norepinephrine boluses combined with crystalloid co-load for preventing post-spinal anesthesia hypotension during cesarean section.

Chengfei Xu, Peipei Zhang, Chunying Dai, Jingjun Zhang, Honghao Wu, Qianying Liu, Zhiqiang Zhang, Fengwei Yin, Huadong Ni, Liang Cheng

Abstract readClinical Trial, Phase IVRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chengfei Xu *Department of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Peipei Zhang *Department of Obstetrics and Gynecology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Chunying DaiDepartment of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Jingjun ZhangDepartment of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Honghao WuDepartment of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Qianying LiuDepartment of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Zhiqiang ZhangDepartment of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Fengwei YinDepartment of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China.
Huadong NiDepartment of Anesthesiology and Pain Research center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing, 314001, China. huadongni@zjxu.edu.cn.
Liang ChengDepartment of Anesthesiology, The Third People's Hospital of Bengbu, 38 Shengli Middle Road, Bengbu, 233000, China. bbchengliang@163.com.

Funding

Bengbu Science and Technology Bureau project 20220115Key Speciality of Anhui Province 2022-AH-105Natural Science Key Program of Bengbu Medical University Natural Science Key Program of Bengbu Medical University 2023byzd113Research Project on the Inheritance and Innovation of Traditional Chinese Medicine of Anhui Province 2024CCCX272Scientific research project of Anhui Provincial Health Commission AHWJ2023A30069
6 · The paper itself

Abstract

backgroundThe use of a fluid co-load has been shown to enhance hemodynamic stability and diminish the occurrence of hypotension after spinal anesthesia when paired with prophylactic norepinephrine. This research aimed to identify the effective dosages (ED

methodsPatients were administered crystalloid co-loads at a dosage of 10 mL/kg, in addition to preventive norepinephrine dosages direct following spinal anesthesia administration. The dosages of norepinephrine were established employing the up-and-down sequential allocation technique, starting with 8 µg and progressively rising by 1 µg increments. The primary objective was to detect the effective dosage (ED

resultsThe ED

conclusionA prophylactic norepinephrine bolus of 5.35 µg, administered with a crystalloid co-load, effectively prevents hypotension following the spinal anesthesia in cesarean delivery patients.

Indexed as

Anesthesia, ObstetricalAnesthesia, SpinalCesarean SectionHypotensionNorepinephrineVasoconstrictor AgentsAdultCrystalloid SolutionsDose-Response Relationship, DrugFemaleHumansIsotonic SolutionsPregnancyCrystalloid SolutionsIsotonic SolutionsNorepinephrineVasoconstrictor AgentsCesarean sectionCrystalloid co-loadNorepinephrinePost-spinal anesthesia hypotension

Identifiers

PMID39856541
PMCPMC11763120

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.