Evidence map›Paper›PMID 39856475›Full record

ReviewCell regeneration (London, England)2025

Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.

Jimpi Langthasa, Li Guan, Shyam Lal Jinagal, Quynh-Thu Le

Abstract readReview
In one paragraph

Review in Cell regeneration (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Organoid-based modeling and regenerative strategies for salivary gland dysfunction.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jimpi LangthasaDepartment of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr Clinic D, Stanford, CA, MC 584794305, USA.
Li GuanDepartment of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr Clinic D, Stanford, CA, MC 584794305, USA.
Shyam Lal JinagalGladstone Institutes, San Francisco, CA, USA.
Quynh-Thu LeDepartment of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr Clinic D, Stanford, CA, MC 584794305, USA. qle@stanford.edu.ORCID http://orcid.org/0000-0002-3682-1439

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4M
Translational Biology CoreP01CA257907 · NCI · STANFORD UNIVERSITY · PI Quynh-Thu Xuan Le · 2022 to 2026
$12.0M
Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic ProgressionU54CA274511 · NCI · STANFORD UNIVERSITY · PI JOSEPH B SHRAGER · 2023 to 2026
$9.5M
Precision imaging for risk stratification and personalized therapy of oropharyngeal cancerR01DE030894 · NIDCR · STANFORD UNIVERSITY · PI Quynh-Thu Xuan Le, Ruijiang Li · 2022 to 2026
$3.0M
The role of Galectin-1 in shaping the immune suppressive landscape in head and neck cancerR01DE029672 · NIDCR · STANFORD UNIVERSITY · PI LE, QUYNH-THU XUAN · 2021 to 2025
$2.9M
Salivary gland response to Desert hedgehog signaling as an antidote to damage from therapeutic radiationR01DE031724 · NIDCR · STANFORD UNIVERSITY · PI PHILIP A BEACHY · 2022 to 2026
$2.5M
NCI NIH HHS P01 CA257907NCI NIH HHS P30 CA124435NCI NIH HHS U54 CA274511NIDCR NIH HHS R01 DE029672NIDCR NIH HHS R01 DE030894NIDCR NIH HHS R01 DE031724NIH HHS NIH P30 CA124435NIH HHS NIH R01 DE029672NIH HHS NIH R01 DE030894NIH HHS NIH R01 DE031724NIH HHS NIH U54 CA274511NIH HHS P01CA257907
6 · The paper itself

Abstract

Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren's syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, and their role in tissue regeneration. Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions.

Indexed as

Clinical implicationsRegenerative medicineSalivary glandsSalivary gland stem/progenitor cells (SSPCs)

Identifiers

PMID39856475
PMCPMC11759724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.