Evidence map›Paper›PMID 39856461›Full record

ArticleBiotechnology letters2025

Lycopodiaceae herb from Vietnam as a promising medicinal source of natural hupezine and novel huperzine-producing endophytic fungi.

Thanh Thi Minh Le, Ha Thi Thu Trinh, Ha Thanh Pham, Dat Tien Nguyen, Giang Hoang Do, Hien Thuy Phan, Tam Duc Le, Ngoc Tung Quach, Tien Quyet Phi, Ha Hoang Chu

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Article in Biotechnology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Thanh Thi Minh LeInstitute of Biotechnology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam. minhthanh.ibt@gmail.com.ORCID http://orcid.org/0000-0001-9128-3285
Ha Thi Thu TrinhInstitute of Biotechnology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam.
Ha Thanh PhamInstitute of Biotechnology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam.
Dat Tien NguyenCenter of Research and Technology Transfer, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam.
Giang Hoang DoCenter of Research and Technology Transfer, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam.
Hien Thuy PhanNational Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, 100000, Vietnam.
Tam Duc LeNational Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, 100000, Vietnam.
Ngoc Tung QuachInstitute of Biotechnology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam.
Tien Quyet PhiInstitute of Biotechnology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam.
Ha Hoang ChuInstitute of Biotechnology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000, Vietnam.

Funding

This research was funded by a Grant from Vietnam Academy of Science and Technology code: VAST.TDCNSH.04/20-22
6 · The paper itself

Abstract

objectives(1) To evaluate the potential of producing huperzine (Hup) and anticholinesterase (AChE) activities of nine native Lycopodiaceae species collected in Vietnam; (2) Isolation, identification and characterization of a novel fungus producing both HupA and HupB isolated from Lycopodium casuarinoides Spring.

resultsAll methanolic extracts of nine plants showed AChE inhibition from 8.55 to 71.81%. Of note, Huperzia serrata (Thunb.) Trevis, L. casuarinoides, Lycopodium clavatum L., Phlegmariurus squarrosus (G. Forst.), and P. phlegmaria (L.) T. Sen & U. Sen were shown to biosynthesize both HupA and HupB by high-performance liquid chromatography (HPLC). Plants H. serrata, L. casuarinoides and L. clavatum showed the most potent AchE IC

conclusionsThese are the first reports of (1) two species L. clavatum and L. casuarinoides producing both HupA and HupB, and (2) L. casuarinoides as novel sources of Hup-producing endophytic fungi as well as (3) fungus Aspergillus as a novel HupA- and HupB-producing endophyte isolated from L. casuarinoides.

Indexed as

AlkaloidsEndophytesFungiLycopodiaceaeSesquiterpenesCholinesterase InhibitorsChromatography, High Pressure LiquidHuperziaPlant ExtractsVietnamAlkaloidsCholinesterase Inhibitorshuperzine APlant ExtractsSesquiterpenesAcetylcholinesterase inhibitionAlzheimer diseaseAspergillusEndophytic fungiHuperzineLycopodiaceaeLycopodium casuarinoidesLycopodium clavatum

Identifiers

PMID39856461

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