Evidence map›Paper›PMID 39856368›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025

Pre-injury narcotic drug use in isolated severe traumatic brain injury: effect on outcomes.

Keishi Yamaguchi, Kyosuke Takahashi, Dominik Andreas Jakob, Takeru Abe, Kazuhide Matsushima, Demetrios Demetriades

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Keishi YamaguchiDivision of Acute Care Surgery, Department of Surgery, University of Southern California, 2051 Marengo Street, Los Angeles, CA, 90033, USA.ORCID http://orcid.org/0000-0002-9568-4059
Kyosuke TakahashiDivision of Acute Care Surgery, Department of Surgery, University of Southern California, 2051 Marengo Street, Los Angeles, CA, 90033, USA.
Dominik Andreas JakobDepartment of Emergency Medicine, Inselspital, University Hospital, University of Bern, Freiburgstrasse 16C, Bern, 3010, Switzerland.
Takeru AbeCenter for Integrated Science and Humanities, Fukushima Medical University, 1Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan.
Kazuhide MatsushimaDivision of Acute Care Surgery, Department of Surgery, University of Southern California, 2051 Marengo Street, Los Angeles, CA, 90033, USA.
Demetrios DemetriadesDivision of Acute Care Surgery, Department of Surgery, University of Southern California, 2051 Marengo Street, Los Angeles, CA, 90033, USA. demetria@med.usc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to explore the association between pre-injury narcotic drug use (opioids, methadone, and/or oxycodone) and outcomes in isolated severe traumatic brain injury (TBI) patients.

methodsACS TQIP study included adult trauma patients (≥ 16 years) with complete drug and alcohol screening. Isolated severe TBI was defined as head trauma with AIS 3-5 and without significant extracranial trauma. Exact matching was used to compare patients with isolated pre-injury narcotic drug use to those with no illicit drug or alcohol use. Patients were matched 1:1 based on the following matching criteria: age, gender, mechanism of injury, Injury Severity Score, systolic blood pressure, head AIS, and comorbidities.

resultsOf 1,846,630 patients, 141,058 had isolated severe head injuries with complete drug and alcohol screenings. After exact matching, 1,560 patients in each group were analyzed. There were no significant differences in hospital mortality, craniectomy rates, complication rates, or length of hospital stay. Patients that tested positive for narcotics had lower rates of mechanical ventilation (16.5% vs. 25.3%, p < 0.01) and shorter ICU stays [3 (2-4) days vs. 3 (2-6) days; p < 0.01].

conclusionPre-injury narcotic drug use in isolated severe TBI is not associates with adverse outcomes. Further research is needed to understand the biochemical and physiological effects of narcotic drugs on TBI outcomes.

Indexed as

Brain Injuries, TraumaticNarcoticsOpioid-Related DisordersSubstance-Related DisordersAdultAnalgesics, OpioidFemaleHospital MortalityHumansInjury Severity ScoreLength of StayMaleMethadoneMiddle AgedRespiration, ArtificialAnalgesics, OpioidMethadoneNarcoticsNarcotic useOutcomesSevere traumatic head injuryTrauma

Identifiers

PMID39856368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.