ArticleScientific reports2025
Effects of perfluorolauric acid exposure on intestinal microbial community and physiological health indicators in mice.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Preventive effect of heat-killed Lactiplantibacillus plantarum FM8 in an ovalbumin-induced food allergy murine model.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Perfluorooctanoic Acid (PFOA) Alters the Structure of the Gut Microbial Community and Colonoid Transcription.Current issues in molecular biology · 2026Article
- Calcium Nitrate Supplementation Improves Meat Quality in Hu Sheep via Microbial and Transcriptomic Regulation.Animals : an open access journal from MDPI · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aims to investigate the effects of Perfluorolauric Acid (PFLA) on the gut microbiota community and the physiological health of mice. The experiment was conducted by setting a control group (CTRL) and an experimental group (PFLA), exposing mice to PFLA and observing changes in their gut microbiota community and physiological health indicators. The results showed that exposure to PFLA significantly altered the β diversity of the gut microbiota in mice, as evidenced by NMDS, PCoA, and PCA analyses, indicating a clear change in microbial community structure between the PFLA group and the CTRL group. Moreover, PFLA led to a decrease in α diversity of the gut microbiota, with certain specific species such as CryptoBacteroides significantly increasing in the PFLA group while Odoribacter_laneus decreased. In terms of physiological health, exposure to PFLA resulted in increased liver inflammation, lipid abnormalities, and caused histological changes in the colon, such as ulcerative colitis and damage to glandular structures. These findings suggest that PFLA has adverse effects on the gut microbiota community and physiological health of mice. This study can provide foundational data and references for the pollution control of PFLA.
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Registered trials
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