ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025
Dose-dependent association of hyperoxia and decreased favorable outcomes in mechanically ventilated patients with traumatic brain injury, a retrospective cohort study.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Utility of Serum Occludin as a Prognostic Biomarker of Severe Traumatic Brain Injury and Mediation Role of Acute Lung Injury: A Two-Center Prospective Cohort Study.International journal of general medicine · 2025Article
- Oxygen targets in patients with septic shock: a retrospective cohort study on the association between hyperoxia and mortality.Frontiers in medicine · 2025Article
- Associations between arterial oxygenation and oxidative stress markers in serum and bronchoalveolar lavage fluid of patients with severe brain injury.Frontiers in neurologyArticle
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Authors and funding
9 authors.
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Abstract
purposeIn patients with traumatic brain injury (TBI), adequate oxygenation is crucial to optimize survival and neurological outcome. However, supranormal oxygen partial pressure (PaO
methodsThis retrospective, single-center cohort study included TBI patients receiving mechanical ventilation for ≥ 72 h. Time-weighted mean PaO
resultsFrom 01/2013 until 12/2021, 290 patients fulfilled the inclusion criteria. Hyperoxia was dose-dependently associated with a worsened functional outcome 3-6 months post-injury. Regarding the first 24 h, odds ratios were 0.959 (95% confidence intervals: 0.932-0.990; p = 0.009) for time-weighted mean PaO
conclusionIn this cohort, hyperoxia within 72 h after admission was dose-dependently associated with an unfavorable neurological outcome after 3-6 months.
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