Trial reportNature medicine2025
Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial.
Abstract readClinical Trial
In one paragraph
Trial report in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Review
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Targeting LOXL4-driven matrix stiffening with acetyldigoxin restores CD8Science advances · 2026Article
- Targeting NUDT21-mediated alternative polyadenylation of oncogenes ameliorates colorectal cancer malignancy and metastasis.British journal of cancer · 2026Article
- Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis.Science advances · 2026Article
- Applications of circulating tumor cells in esophageal cancer detection and treatment.Discover oncology · 2026Review
- HIF inhibition: Current strategies and clinical challenges.Redox biology · 2026Review
- Synergistic Effect of Digoxin and Cisplatin on Redox Imbalance in HeLa Cells.Cell biochemistry and function · 2026Article
- CTC cluster in breast cancer: synergetic metastasis promotion mechanism and transformation path from platelet cloaking to leukocyte escort.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Cascading inertial microfluidics for high-throughput, multi-scale enrichment of tumor cells and intact clusters towards enhanced malignancy diagnosis.Microsystems & nanoengineering · 2026Article
- Circulating Tumor Cells: Emerging Frontiers in Cancer Technology.Expert reviews in molecular medicine · 2026Review
- Review
- Pathophysiological Roles of Two Intracellular P-Type ATPases: The Cancer-Associated NaInternational journal of molecular sciences · 2026Review
- Liquid biopsies in precision oncology for older adults with cancer.NPJ precision oncology · 2026Review
- Article
- Role of circulating tumor cell clusters in breast cancer.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2026Review
- Novel therapeutic strategies for ccRCC through integration of systemic drug combinations and oncolytic adenovirus immunotherapy.Frontiers in immunology · 2026Article
- Assessment of Imaging Mass Cytometry (IMC) as a Tool to Characterize Circulating Tumor Cells (CTCs) in Preclinical Mouse Models.bioRxiv : the preprint server for biology · 2025Article
- PAK2 promotes CTC cluster formation by phosphorylating E-cadherin to enhance cell-cell adhesion in breast cancer.Breast cancer research : BCR · 2025Article
- The mechanism of action of digoxin requires the sodium-dependent inactivation of the sodium-calcium exchanger.Science advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Christian Kurzeder *Department of Gynecology and Gynecologic Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
Bich Doan Nguyen-Sträuli *Department of Gynecology and Gynecologic Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-1290-830X
Ilona Krol *Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Alexander Ring *Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Francesc Castro-GinerDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-6111-0754
Manuel NüeschDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Simran AsawaDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Yu Wei ZhangDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Selina BudinjasDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Ana GvozdenovicDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Maren VogelDepartment of Gynecology and Gynecologic Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
Angela KohlerCenter of Oncology and Hematology, Medical University Clinic, Kantonsspital Baselland, Liestal, Switzerland.
Cvetka Grašič KuharBreast Center, University Hospital Basel, University of Basel, Basel, Switzerland.
Fabienne D SchwabDepartment of Gynecology and Gynecologic Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
Viola Heinzelmann-SchwarzDepartment of Gynecology and Gynecologic Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
Walter Paul WeberBreast Center, University Hospital Basel, University of Basel, Basel, Switzerland.
Christoph RochlitzDepartment of Medical Oncology, University Hospital Basel, Basel, Switzerland.
Denise VorburgerDepartment of Gynecology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5960-8414
Heike Frauchiger-HeuerDepartment of Gynecology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-2311-5412
Isabell WitzelDepartment of Gynecology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Andreas WickiDepartment of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-2924-8080
Gabriela M KusterDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-8209-4631
Marcus VetterCancer Center Baselland, Medical University Clinic, Kantonsspital Baselland, Liestal, Switzerland. marcus.vetter@ksbl.ch.ORCID http://orcid.org/0009-0004-1003-1078
Nicola AcetoDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland. naceto@ethz.ch.ORCID http://orcid.org/0000-0001-9579-6918
Funding
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101001652Wellcome Trust 212183
Abstract
The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety of cancer types. In breast cancer, preclinical studies showed that inhibitors of the Na
Indexed as
Breast NeoplasmsDigoxinNeoplastic Cells, CirculatingAdultAgedCell AdhesionFemaleHumansMiddle AgedNeoplasm MetastasisProof of Concept StudyProspective StudiesSodium-Potassium-Exchanging ATPaseDigoxinSodium-Potassium-Exchanging ATPase
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.