ArticleNature medicine2025
Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria.
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Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- Article
- Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria.bioRxiv : the preprint server for biology · 2026Article
- Gut bacterial dysbiosis in pediatric severe malaria associates with post-discharge mortality.Nature communications · 2025Article
- Elevating uric acid as an antimalarial target.Trends in parasitology · 2025Article
Corrections and comments
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Authors and funding
20 authors.
Caitlin BondRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Olivia J BednarskiRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-3029-8461
Dibyadyuti DattaRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Ruth NamazziDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Robert O OpokaAga Khan University East Africa Medical College, Nairobi, Kenya.
Giselle Lima-CooperRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Anthony BatteChild Health and Development Centre, Makerere University College of Health Sciences, Kampala, Uganda.
Keerthi UdumulaRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Deepali BalasubramaniRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Marilyn VasquezDepartment of Microbiology, New York University School of Medicine, New York City, NY, USA.
Ana RodriguezDepartment of Microbiology, New York University School of Medicine, New York City, NY, USA.
Claire LiepmannRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Paul BangiranaDepartment of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda.
Marco AbreuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Tae-Hwi Schwantes-AnDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Yi ZhaoDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-4766-5934
Tarek M El-AchkarDivision of Nephrology, Indiana University and the Roudebush Indianapolis VA Medical Center, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-4645-3614
Nathan W SchmidtRyan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-7325-4536
Chandy C John *Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA. chjohn@iu.edu.ORCID http://orcid.org/0000-0002-1634-1411
Andrea L Conroy *Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-5328-6511
Funding
Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2MGut microbiota and human malariaR01AI148525 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI JOHN, CHANDY C., SCHMIDT, NATHAN · 2020 to 2024
$3.6MMalaria associated pathogenesis of chronic kidney disease (MAP-CKD)R01AI165946 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Andrea L. Conroy · 2022 to 2026
$3.2MNRSA Training CoreTL1TR002531 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI FOTI, DANIEL JUSTIN, HURLEY, THOMAS D. · 2018 to 2022
$2.5MTargeting the compromised brain endothelial barrier function during cerebral malaria with AT2 receptor agonistsR01HL150145 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RODRIGUEZ, ANA, STITT, ALAN · 2020 to 2023
$2.0MResearch training in infection, nutrition and neurodevelopment in UgandaD43TW010928 · FIC · INDIANA UNIVERSITY INDIANAPOLIS · PI Chandy C. John · 2018 to 2026
$1.9MRegulation of brain endothelial integrity by angiotensin receptors as treatment for cerebral malariaR01NS105910 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RODRIGUEZ, ANA, WALTHER, THOMAS · 2018 to 2022
$1.6MIndiana University Kidney Training Program (IU-KTP)T32DK120524 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M · 2019 to 2023
$1.3MMechanisms of acute kidney injury in malaria - Resubmission - 1R21AI151349 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RODRIGUEZ, ANA · 2021 to 2022
$476kFIC NIH HHS D43 TW010928NCATS NIH HHS TL1 TR002531NHLBI NIH HHS R01 HL150145NIAID NIH HHS R01 AI148525NIAID NIH HHS R01 AI165946NIAID NIH HHS R21 AI151349NIDDK NIH HHS T32 DK120524NINDS NIH HHS R01 NS055349NINDS NIH HHS R01 NS105910U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) TL1TR002531U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL150145U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 3R01HL150145-02S1U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R21AI151349U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI148525U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 5T32DK120524-05U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R01NS105910U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01AI165946U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS055349
Abstract
We investigated the role of uric acid in the pathogenesis of severe malaria (SM) in two independent cohorts of children with SM. Hyperuricemia (blood uric acid ≥ 7 mg dl
Indexed as
Cognitive DysfunctionHyperuricemiaMalariaUric AcidChildChild, PreschoolFemaleHumansInfantMaleUric Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.