Evidence map›Paper›PMID 39856067›Full record

ReviewNPJ breast cancer2025

Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes.

Fresia Pareja, Rohit Bhargava, Virginia F Borges, Edi Brogi, Rita Canas Marques, Fatima Cardoso, Christine Desmedt, Malini Harigopal, Sunil R Lakhani, Adrian Lee and 18 more

Abstract readReview
In one paragraph

Review in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Fresia ParejaDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. parejaf@mskcc.org.ORCID http://orcid.org/0000-0003-3748-8049
Rohit BhargavaDepartment of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-1225-8418
Virginia F BorgesDivision of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-1158-7524
Edi BrogiDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4737-8468
Rita Canas MarquesDepartment of Pathology, Champalimaud Foundation, Lisbon, Portugal.
Fatima CardosoBreast Unit, Champalimaud Clinical Centre/Champalimaud Foundation, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-6692-2249
Christine DesmedtLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5223-5579
Malini HarigopalDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sunil R LakhaniUQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, and Pathology Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1879-2555
Adrian LeeWomen's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillmann Cancer Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9917-514X
Jose Pablo LeoneDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8537-652X
Hannah LindenDivision of Hematology and Oncology, Fred Hutchinson Cancer Center/University of Washington, Seattle, WA, USA.
Christopher J LordThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-3226-0515
Caterina MarchioCandiolo Cancer Institute, FPO - IRCCS, Candiolo, Turin, Italy.ORCID http://orcid.org/0000-0003-2024-6131
Sofia D MerajverBreast and Ovarian Cancer Risk Evaluation Program, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6823-7130
Emad RakhaDepartment of Pathology, School of Medicine, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK.ORCID http://orcid.org/0000-0002-5009-5525
Jorge S Reis-FilhoDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2969-3173
Andrea RichardsonDepartment of Pathology, John Hopkins Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5221-1094
Elinor SawyerSchool of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, Guy's Cancer Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0001-8285-4111
Pepper SchedinKnight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-4244-987X
Christopher J SchwartzDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8086-8429
Andrew TuttThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-8715-2901
Naoto T UenoBreast Medical Oncology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Anne Vincent-SalomonDepartment of Pathology, Curie Institute, Paris Sciences Lettres University, Paris, France.ORCID http://orcid.org/0000-0001-5754-5771
Britta WeigeltDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9927-1270
Y Hannah WenDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stuart J SchnittDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA. sschnitt@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-3608-7828
Steffi OesterreichWomen's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillmann Cancer Center, Pittsburgh, PA, USA. oesterreichs@upmbc.edu.ORCID http://orcid.org/0000-0002-2537-6923

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Targeting Polθ to Overcome PARP Inhibitor Resistance in Homologous Recombination Deficient Breast CancerP50CA247749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Sarat Chandarlapaty, Simon N. Powell · 2020 to 2026
$16.3M
NSAIDs During Postpartum Involution for Breast Cancer ChemopreventionR01CA169175 · NCI · UNIVERSITY OF COLORADO DENVER · PI SCHEDIN, PEPPER J · 2013 to 2024
$4.8M
Breast Cancer Research Foundation (BCRF) AACR-BRCF 09-06-26BORGNCI NIH HHS P30 CA008748NCI NIH HHS P50 CA247749NCI NIH HHS R01 CA169175U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA008748U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P50 CA24779 01
6 · The paper itself

Abstract

Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored.

Identifiers

PMID39856067
PMCPMC11760369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.