Evidence map›Paper›PMID 39855990›Full record

ReviewTrends in immunology2025

Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments.

Romi Gupta, Raj Kumar, Courtney A Penn, Narendra Wajapeyee

Abstract readReview
In one paragraph

Review in Trends in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  17. Integrative and deep learning-based prediction of therapy response in ovarian cancer.Journal of experimental & clinical cancer research : CR · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Romi GuptaDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, AL 35233, USA. Electronic address: romigup@uab.edu.
Raj KumarDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Courtney A PennDivision of Gynecological Oncology, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Narendra WajapeyeeDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, AL 35233, USA. Electronic address: nwajapey@uab.edu.

Funding

Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinomaR01CA257046 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WAJAPEYEE, NARENDRA · 2021 to 2025
$2.3M
Role of EZH2 as a Driver and Therapeutic Target of Hepatocellular CarcinomaR01CA271613 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MICHELLE ALICE KELLIHER, Narendra Wajapeyee · 2023 to 2026
$1.8M
CRISPR and Humanized mice-based Discovery of a Novel Drug target for HCC TherapyR21CA288243 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WAJAPEYEE, NARENDRA · 2024 to 2025
$382k
NCI NIH HHS R01 CA257046NCI NIH HHS R01 CA271613NCI NIH HHS R21 CA288243
6 · The paper itself

Abstract

Ovarian cancer (OC) is the most lethal gynecologic malignancy, characterized by multiple histological subtypes, each with distinct pathological and clinical features. Current treatment approaches include cytotoxic chemotherapies, poly(ADP-ribose) polymerase (PARP) inhibitors, bevacizumab, hormonal therapy, immunotherapy, and antibody-drug conjugates (ADCs). In this review we discuss immune evasion mechanisms in OC and the role of genetics, the tumor microenvironment, and tumor heterogeneity in influencing these processes. We also discuss the use of immunotherapies for OC treatment, either alone or in combination with other anticancer agents, with a focus on their clinical outcomes. Finally, we highlight emerging immunotherapies that have either succeeded or are on the verge of significantly impacting cancer treatment, and we discuss their potential utility in the effective treatment of OC.

Indexed as

Immune EvasionImmunotherapyOvarian NeoplasmsTumor EscapeAnimalsFemaleHumansTumor Microenvironmentadaptive immunityimmunotherapyinnate immunityovarian cancertumor heterogeneity

Identifiers

PMID39855990
PMCPMC11835538

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.