CRISPR: fundamental principles and implications for anaesthesia.

Alexendar R Perez, Orestes Mavrothalassitis, Janice S Chen, Judith Hellman, Michael A Gropper

Abstract readReview

In one paragraph

Review in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexendar R PerezDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Silico Therapeutics, Inc., San Jose, CA, USA. Electronic address: Alexendar.Perez@ucsf.edu.

Orestes MavrothalassitisDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.

Janice S ChenMammoth Biosciences, Inc., Brisbane, CA, USA.

Judith HellmanDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.

Michael A GropperDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA, USA.

Funding

Promoting Multidisciplinary Clinical and Translational Science in Aging by Resident InvestigatorsR38AG070171 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alison Huang, Ashwin Ajit Kotwal · 2021 to 2026

$1.8M

NIA NIH HHS R38 AG070171

6 · The paper itself

Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR)-based medical therapies are increasingly gaining regulatory approval worldwide. Consequently, patients receiving CRISPR therapy will come under the care of anaesthesiologists. An understanding of CRISPR, its technological implementations, and the characteristics of patients likely to receive this therapy will be essential to caring for this patient population. However, the role of CRISPR in anaesthesiology extends beyond simply caring for patients with prior CRISPR therapy. CRISPR has multiple direct potential applications in anaesthesia, particularly for managing chronic pain and critical illness. Additionally, given the unique skills anaesthesiologists possess, CRISPR potentially allows new roles for anaesthesiologists in the field of oncology. Consequently, CRISPR technology could enable new domains of anaesthetic practice. This review provides a primer on CRISPR for anaesthesiologists and an overview on how the technology could impact the field.

Indexed as

AnesthesiaAnesthesiologyClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsGene EditingGenetic TherapyHumanschronic painCRISPRcritical caregenome engineeringoncology

Identifiers

PMID39855935

DOI10.1016/j.bja.2024.11.040

PMCPMC11867086

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.