Evidence map›Paper›PMID 39855635›Full record

ArticleJournal of medicinal chemistry2025

Discovery of the First Efficacious Adenosine 2A Receptor Negative Allosteric Modulators for High Adenosine Cancer Immunotherapies.

Margot Boujut, Margaux Héritier, Aurélie Gouiller, Camille Süess, Alessandro Scapozza, Thibaut De Smedt, Maxime Guibert, Sébastien Tardy, Hesham M Ismail, David Pejoski and 1 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Negative Allosteric Modulators of AJournal of medicinal chemistry · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Margot BoujutSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.ORCID 0009-0009-4479-1231
Margaux HéritierSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.ORCID 0000-0002-8394-0406
Aurélie GouillerSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.
Camille SüessSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.
Alessandro ScapozzaSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.ORCID 0009-0000-2232-6974
Thibaut De SmedtSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.
Maxime GuibertSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.ORCID 0009-0006-5013-2193
Sébastien TardySchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.ORCID 0000-0001-9884-601X
Hesham M IsmailSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.
David PejoskiSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.
Leonardo ScapozzaSchool of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of the adenosine 2A receptor (A

Indexed as

ImmunotherapyReceptor, Adenosine A2AAdenosineAdenosine A2 Receptor AntagonistsAllosteric RegulationAnimalsCHO CellsCricetulusDrug DiscoveryHumansNeoplasmsNitrilesPyridinesStructure-Activity RelationshipAdenosineAdenosine A2 Receptor AntagonistsNitrilesPyridinesReceptor, Adenosine A2A

Identifiers

PMID39855635
PMCPMC11873987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.