ArticleJournal of affective disorders2025
Oral microbiota among treatment-naïve adolescents with depression: A case-control study.
Article in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory biomarkers and oral microbiome alterations in depression and anxiety disorders: a systematic review.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2026Pooled it
- Microbiome-Informed Precision Electroconvulsive Therapy: Oral-Gut-Immune Signatures and Seizure Biology as Candidate Predictors of Response-A Narrative Review.Biomedicines · 2026Review
- Dynamic changes in oral microbiome composition during early childhood caries management.Applied microbiology and biotechnology · 2026Article
- Dynamic interactions between gut microbiome and host lipidome in antenatal depression: a large longitudinal study.Molecular psychiatry · 2026Article
- The association of depression and oral microbiota.Scientific reports · 2025Article
- Association Between Oral Dysbiosis and Depression: A Systematic Review.Journal of clinical medicine · 2025Review
- Antidepressant Effect of Short-Chain Fatty Acids on Chronic Unpredictable Mild Stress in Model Rats And Their Influence on the Oral-Gut Microbiota.Neuropsychiatric disease and treatment · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundAdolescent depression has profound impacts on physical, cognitive, and emotional development. While gut microbiota changes have been linked to depression, the relationship between oral microbiota and depression remains elusive. Our study aims to investigate the oral microbiota in treatment-naïve adolescents experiencing depression and examine their potential associations with cognitive function.
methodsOur case-control study comprised two groups of adolescents aged 12-17: the depression group, including treatment-naïve individuals diagnosed with DSM-5 major depressive disorder (MDD), and a healthy control group of non-depressed individuals (HC). Participants underwent structured neuropsychiatric assessments, and fasting morning saliva samples were collected for the 16S rRNA sequencing to investigate the oral microbiota.
resultsSignificant differences were identified in the α- and β-diversities of the oral microbiota between MDD and HC groups. Specific bacterial taxa, including genera Streptococcus, Neisseria, Hemophilus, Fusobacterium, and g_norank_f_norank_o_Absconditabacteriales_SR1, were significantly associated with MDD. The association extends to cognitive functions, where correlations were observed between certain oral bacteria and cognitive scores, including instant and delayed memory, visual breadth, and speech features for the combined MDD and HC individuals (p < 0.05). Random forest analysis identified ten genera of oral microbes with the highest predictive values for MDD. The area under the curve (AUC) is 0.78 in the receiver operating characteristic (ROC) curve analysis.
conclusionOur results highlight the oral microbiota's role as a biomarker for adolescent depression and its impact on cognitive functions. These insights underscore the need for further research into the links between oral health, mental health, and cognitive functions.
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