Evidence map›Paper›PMID 39855480›Full record

ArticleRespiratory medicine2025

Antinuclear antibodies and progression of quantitative interstitial lung changes: The Multi-Ethnic Study of Atherosclerosis (MESA)-Lung Study.

Kathryn Friedman Flack, Michael D George, John S Kim, Jesse Y Hsu, Anna J Podolanczuk, Eric A Hoffman, Cheilonda Johnson, Claire F McGroder, Benjamin M Smith, Maryl Kreider and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kathryn Friedman FlackHospital of the University of Pennsylvania, Philadelphia, PA, United States.
Michael D GeorgeHospital of the University of Pennsylvania, Philadelphia, PA, United States.
John S KimUniversity of Virginia School of Medicine, Charlottesville, VA, United States; Columbia University Medical Center, New York, NY, United States.
Jesse Y HsuHospital of the University of Pennsylvania, Philadelphia, PA, United States.
Anna J PodolanczukWeill Cornell Medical College, New York, NY, United States.
Eric A HoffmanUniv of Iowa Carver Coll of Med, Iowa City, IA, United States.
Cheilonda JohnsonHospital of the University of Pennsylvania, Philadelphia, PA, United States.
Claire F McGroderColumbia University Medical Center, New York, NY, United States.
Benjamin M SmithColumbia University Medical Center, New York, NY, United States; McGill University, Montreal, Canada.
Maryl KreiderHospital of the University of Pennsylvania, Philadelphia, PA, United States.
Steven M KawutHospital of the University of Pennsylvania, Philadelphia, PA, United States.
R Graham BarrColumbia University Medical Center, New York, NY, United States.
Michaela R AndersonHospital of the University of Pennsylvania, Philadelphia, PA, United States. Electronic address: Michaela.Anderson@pennmedicine.upenn.edu.
Elana J BernsteinColumbia University Medical Center, New York, NY, United States.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Data, Modeling,and Coordination Center for PrecISE NetworkU24HL138998 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANSTROM, KEVIN J, IVANOVA, ANASTASIA · 2017 to 2022
$44.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Andrea Adamcakova-Dodd · 1990 to 2026
$40.5M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Rapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
Understanding the Origins of Early COPDR01HL144718 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CURTIS, JEFFREY LOUIS, HAN, MEILAN K · 2020 to 2024
$11.3M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCI NIH HHS R01 CA267820NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K23 HL140199NHLBI NIH HHS K23 HL150280NHLBI NIH HHS K23 HL150301NHLBI NIH HHS L30 HL143645NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL121270NHLBI NIH HHS R01 HL130506NHLBI NIH HHS R01 HL143998NHLBI NIH HHS R01 HL144718NHLBI NIH HHS R01 HL155293NHLBI NIH HHS R01 HL155576NHLBI NIH HHS R01 HL155816NHLBI NIH HHS R01 HL157634NHLBI NIH HHS R01 HL164758NHLBI NIH HHS R01 HL168116NHLBI NIH HHS R01 HL169765NHLBI NIH HHS RC1 HL100543NHLBI NIH HHS T32 HL007891NHLBI NIH HHS T32 HL144461NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U24 HL138998NHLBI NIH HHS UG3 HL154944NIAMS NIH HHS K23 AR073931NIAMS NIH HHS K23 AR075112NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Antinuclear antibodies (ANA) are often found in ILD; whether ANA is associated with radiographic progression of quantitive interstitial lung changes is unknown. We performed longitudinal analyses of adults in the Multi-Ethnic Study of Atherosclerosis using linear mixed effects models with random intercept and slope to evaluate whether baseline ANA was associated with change in the amount of lung with high attenuation areas on CT (HAAs, percentage of imaged lung with -600 to -250 HU). In 6,638 subjects with 17,293 CT scans over 18 years, 741 (11 %) were ANA positive. ANA was not associated with HAA progression with ANA as a dichotomous variable (0.13 % less progression per year for ANA positive vs negative, 95%CI -0.33 %-0.07 %, p = 0.19) or as a continuous variable (0.004 % less progression per year per 10 % increase in ANA, 95%CI -0.01 %-0.005 %, p = 0.37). ANA was not associated with progression of HAA in community dwelling adults.

Indexed as

Antibodies, AntinuclearAtherosclerosisLung Diseases, InterstitialAgedAged, 80 and overDisease ProgressionFemaleHumansLongitudinal StudiesLungMaleMiddle AgedTomography, X-Ray ComputedAntibodies, AntinuclearAntinuclear antibodiesAutoantibodiesHigh attenuation areasSubclinical interstitial lung disease

Identifiers

PMID39855480
PMCPMC11851077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.